Card11^m8Btlr
Chemically induced Allele Detail

Summary

• Symbol: Card11^m8Btlr
• Name: caspase recruitment domain family, member 11; mutation 8, Bruce Beutler
• MGI ID: MGI:6305368
• Synonyms: unmodulated2
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^m8Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: G to T (or C>A on the reverse (gene) strand) substitution at base pair 140,883,782 (v38) on chromosome 5, or base pair 116,815 in the GenBank genomic region NC_000071 encodingCard11 within intron 17. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of a cryptic splice acceptor site in intron 17. Use of a cryptic site in intron 17 would result in the addition of 10 base pairs to the 5' end of exon 18, leading to a frame-shifted protein product beginning after amino acid 756 of the protein, which is normally 1,154 amino acids in length, and terminating after the inclusion of 44 aberrant amino acids. (J:274940)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=2583

References

• Original: J:274940 Choi JH, et al., Mutagenetix entry for unmodulated2. MGI Direct Data Submission. 2019
• All: 1 reference(s)