Phenotypes associated with this allele

• Allele Symbol: Card11^m8Btlr
• Allele Name: mutation 8, Bruce Beutler
• Allele ID: MGI:6305368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^m8Btlr/Card11^m8Btlr	C57BL/6J-Card11^m8Btlr	MGI:6305370

Genotype
MGI:6305370

hm1

• Allelic Composition: Card11^m8Btlr/Card11^m8Btlr
• Genetic Background: C57BL/6J-Card11^m8Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:274940 )

• reduced expression of B220 on peripheral blood B cells and increased expression of IgM on peripheral blood B cells

increased B-1b cell number ( J:274940 )

• increased frequency of B1b cells in B1 cells in the peripheral blood

decreased B cell number ( J:274940 )

• decreased frequency of IgM+ B cells in the peripheral blood

• decrease in the peripheral blood B to T cell ratio

decreased B-1a cell number ( J:274940 )

• decreased frequency of B1a cells in B1 cells in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274940 )

• reduced frequency of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274940 )

• increased frequency of total T cells in the peripheral blood

• decrease in the peripheral blood B to T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274940 )

• increased frequency of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274940 )

• increased frequency of CD8+ T cells in the peripheral blood

increased NK T cell number ( J:274940 )

• increased frequency of NK T cells in the peripheral blood

decreased IgG level ( J:274940 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFV--gal) was diminished

decreased IgM level ( J:274940 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

impaired humoral immune response ( J:274940 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFV--gal) was diminished

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

decreased response to antigen ( J:274940 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFV--gal) was diminished

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system

abnormal B cell differentiation ( J:274940 )

• reduced expression of B220 on peripheral blood B cells and increased expression of IgM on peripheral blood B cells

increased B-1b cell number ( J:274940 )

• increased frequency of B1b cells in B1 cells in the peripheral blood

decreased B cell number ( J:274940 )

• decreased frequency of IgM+ B cells in the peripheral blood

• decrease in the peripheral blood B to T cell ratio

decreased B-1a cell number ( J:274940 )

• decreased frequency of B1a cells in B1 cells in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274940 )

• reduced frequency of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274940 )

• increased frequency of total T cells in the peripheral blood

• decrease in the peripheral blood B to T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274940 )

• increased frequency of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274940 )

• increased frequency of CD8+ T cells in the peripheral blood

increased NK T cell number ( J:274940 )

• increased frequency of NK T cells in the peripheral blood

decreased IgG level ( J:274940 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFV--gal) was diminished

decreased IgM level ( J:274940 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)