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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nbn
nibrin
MGI:1351625
97 phenotypes from 18 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nbnem1Jpt/Nbnem1Jpt
Not Specified 		normal mortality/aging J:251434
Nbnem2Jpt/Nbnem2Jpt
Not Specified 		normal mortality/aging J:251434
Nbnem3Jpt/Nbnem3Jpt
Not Specified 		increased cellular sensitivity to ionizing radiation J:251434
normal mortality/aging J:251434
normal neoplasm J:251434
Nbnem4Jpt/Nbnem4Jpt
Not Specified 		increased cellular sensitivity to ionizing radiation J:251434
normal mortality/aging J:251434
normal neoplasm J:251434
Nbnem5Jpt/Nbnem5Jpt
Not Specified 		prenatal lethality, complete penetrance J:251434
Nbnem6Jpt/Nbnem6Jpt
Not Specified 		prenatal lethality, complete penetrance J:251434
Nbnem7Jpt/Nbnem7Jpt
Not Specified 		prenatal lethality, complete penetrance J:251434
Nbnem7Jpt/Nbntm2Zqw
Tg(VAV1-cre)1Graf/0
involves: 129P2/OlaHsd 		abnormal T cell morphology J:277750
absent mature B cells J:277750
decreased B cell number J:277750
decreased bone marrow cell number J:277750
decreased erythrocyte cell number J:277750
decreased leukocyte cell number J:277750
decreased myeloid cell number J:277750
decreased T cell number J:277750
decreased thymocyte number J:277750
impaired hematopoiesis J:277750
increased CD8-positive, alpha-beta T cell number J:277750
increased pro-B cell number J:277750
increased T cell acute lymphoblastic leukemia incidence J:277750
increased T cell derived lymphoma incidence J:277750
premature death J:277750
thrombocytosis J:277750
Nbntm1.1Md/Nbntm1.1Md
involves: 129/Sv * 129P2/OlaHsd 		prenatal lethality, complete penetrance J:93598
Nbntm1Jpt/Nbntm1Jpt
involves: 129S7/SvEvBrd 		abnormal cell cycle checkpoint function J:75956
normal cellular phenotype J:144172
chromosome breakage J:75956
normal immune system phenotype J:75956
increased cellular sensitivity to gamma-irradiation J:75956
normal neoplasm J:75956
normal reproductive system phenotype J:75956
Nbntm1Md/Nbntm1Zqw
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA 		chromosome breakage J:93598
Nbntm1Nus/Nbn+
involves: 129 * C57BL/6 		normal neoplasm J:68993
Nbntm1Nus/Nbntm1Nus
involves: 129 * C57BL/6 		abnormal extraembryonic tissue morphology J:68993
absent embryonic epiblast J:68993
absent extraembryonic ectoderm J:68993
absent proamniotic cavity J:68993
decreased embryo size J:68993
decreased inner cell mass proliferation J:68993
disorganized embryonic tissue J:68993
embryonic lethality between implantation and somite formation, complete penetrance J:68993
inner cell mass degeneration J:68993
Nbntm1Nus/Nbntm2Nus
Tg(CD19-cre/ERT2)1Cgn/0
Not Specified 		abnormal B cell physiology J:96102
decreased B cell proliferation J:96102
decreased IgG1 level J:96102
decreased IgG2a level J:96102
decreased IgG2b level J:96102
decreased IgG3 level J:96102
decreased IgG level J:96102
Nbntm1Nus/Nbntm2Nus
Tg(Spo11-cre)D5Mpel/0
involves: BALB/c * C57BL/6 		decreased oocyte number J:166888
normal reproductive system phenotype J:166888
small ovary J:166888
Nbntm1Xu/Nbntm1Xu
Not Specified 		abnormal cell cycle J:75272
abnormal cell-mediated immunity J:75272
absent oocytes J:75272
absent ovarian follicles J:75272
decreased body weight J:75272
decreased CD4-positive, alpha-beta T cell number J:75272
decreased fibroblast proliferation J:75272
decreased mature B cell number J:75272
decreased pre-B cell number J:75272
decreased T cell number J:75272
female infertility J:75272
increased cellular sensitivity to gamma-irradiation J:75272
increased mortality induced by gamma-irradiation J:75272
increased T cell derived lymphoma incidence J:75272
normal nervous system phenotype J:75272
ovary degeneration J:75272
postnatal growth retardation J:75272
thymus hypoplasia J:75272
Nbntm1Zqw/Nbn+
involves: 129S2/SvPas * C57BL/6 		chromosomal instability J:86563
decreased tumor latency J:86563
increased B cell derived lymphoma incidence J:86563
increased gonad tumor incidence J:86563
increased incidence of tumors by ionizing radiation induction J:86563
increased Leydig cell tumor incidence J:86563
increased liver adenocarcinoma incidence J:86563
increased liver adenoma incidence J:86563
increased lung adenocarcinoma incidence J:86563
increased lymphoma incidence J:86563
increased mammary adenocarcinoma incidence J:86563
increased mortality induced by gamma-irradiation J:86563
increased prostate intraepithelial neoplasia incidence J:86563
increased T cell derived lymphoma incidence J:86563
increased thyroid adenoma incidence J:86563
increased tumor incidence J:86563
Nbntm1Zqw/Nbntm1Zqw
involves: 129S2/SvPas * C57BL/6 		abnormal inner cell mass apoptosis J:86563
abnormal trophectoderm morphology J:86563
absent inner cell mass proliferation J:86563
embryonic lethality between implantation and somite formation, complete penetrance J:86563
increased apoptosis J:86563
inner cell mass degeneration J:86563
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129 		decreased cellular sensitivity to ionizing radiation J:129762
Nbntm2Zqw/Nbntm2.1Zqw
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal astrocyte morphology J:98316
abnormal cerebellar granule layer morphology J:98316
abnormal cerebellar Purkinje cell layer J:98316
abnormal cerebellum external granule cell layer morphology J:98316
abnormal gait J:98316
abnormal neuron differentiation J:98316
abnormal reflex J:98316
absent cerebellar foliation J:98316
akinesia J:98316
ataxia J:98316
decreased brain weight J:98316
impaired balance J:98316
increased stereotypic behavior J:98316
postnatal growth retardation J:98316
small cerebellum J:98316
tremors J:98316
Nbntm2Zqw/Nbntm2Zqw
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal astrocyte morphology J:98316
abnormal cerebellar Purkinje cell layer J:98316
abnormal cerebellum external granule cell layer morphology J:98316
abnormal gait J:98316
abnormal involuntary movement J:98316
abnormal neuron differentiation J:98316
absent cerebellar foliation J:98316
akinesia J:98316
ataxia J:98316
decreased brain weight J:98316
impaired balance J:98316
increased stereotypic behavior J:98316
postnatal growth retardation J:98316
small cerebellum J:98316
tremors J:98316
Nbntm2Zqw/Nbntm2Zqw
Tg(VAV1-cre)1Graf/0
involves: 129P2/OlaHsd 		abnormal bone marrow development J:251434
anemia J:277750
decreased erythrocyte cell number J:251434
decreased leukocyte cell number J:251434
postnatal lethality J:251434, J:277750
Nbntm3Jpt/Nbntm3Jpt
involves: 129 		decreased cellular sensitivity to ionizing radiation J:144172
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory