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Nbnem3Jpt
Endonuclease-mediated Allele Detail
Summary
Symbol: Nbnem3Jpt
Name: nibrin; endonuclease-mediated mutation 3, John H Petrini
MGI ID: MGI:6771581
Synonyms: Nbs1mid3
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Alliance: Nbnem3Jpt page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Intragenic deletion
 
Mutation detailsTALEN-mediated genome-editing generated a 3 bp deletion (TTT) in the Mre11 interacting domain of exon 13, deleting the first phenylalanine in the LKNFKKFKK sequence of the Mre11 interacting domain. (J:251434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  59 strains or lines available
References
Original:  J:251434 Kim JH, et al., The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep. 2017 Jan 10;18(2):496-507
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory