Dok3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dok3
docking protein 3
MGI:1351490

13 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dok1^tm1Ppp/Dok1^tm1Ppp Dok2^tm1Ppp/Dok2^tm1Ppp Dok3^tm1Ppp/Dok3^tm1Ppp 129S1/Sv-Dok1^tm1Ppp Dok2^tm1Ppp Dok3^tm1Ppp	abnormal pulmonary alveolus morphology	J:158011
	increased bronchioalveolar stem cell number	J:158011
	increased chronic myelocytic leukemia incidence	J:158011
	increased leukocyte cell number	J:158011
	increased lung adenocarcinoma incidence	J:158011
	increased lung tumor incidence	J:158011
	increased type II pneumocyte number	J:158011
	premature death	J:158011
	pulmonary hyperplasia	J:158011
Dok1^tm1Ppp/Dok1^tm1Ppp Dok3^tm1Ppp/Dok3^tm1Ppp 129S1/Sv-Dok1^tm1Ppp Dok3^tm1Ppp	increased lung adenocarcinoma incidence	J:158011
Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam Dok3^tm1Brs/Dok3^tm1Brs involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal macrophage physiology	J:163407
	increased histiocytic sarcoma incidence	J:163407
	increased macrophage cell number	J:163407
	increased tumor incidence	J:163407
	premature death	J:163407

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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