Dok3 MGI Mouse Gene Detail - MGI:1351490

Symbol

Dok3
Name

docking protein 3
Synonyms

p62Dok-like protein

Feature Type

protein coding gene
IDs

MGI:1351490
NCBI Gene: 27261
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:55671044-55677109 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

1 experiment

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351490	protein coding gene	Chr13:55671044-55678158 (-)
129S1/SvImJ	ENSMUSG00200016468	protein coding gene	Chr13:52543630-52549857 (-)
A/J	ENSMUSG00195039539	protein coding gene	Chr13:52002432-52008656 (-)
AKR/J	ENSMUSG00220041467	protein coding gene	Chr13:51551004-51557231 (-)
BALB/cJ	ENSMUSG00180015938	protein coding gene	Chr13:52253695-52259920 (-)
C3H/HeJ	ENSMUSG00175036383	protein coding gene	Chr13:52040147-52046371 (-)
C57BL/6NJ	ENSMUSG00215030779	protein coding gene	Chr13:52073088-52079316 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018567	protein coding gene	Chr13:50916183-50921723 (-)
CAST/EiJ	ENSTCUG00005039361	protein coding gene	Chr13:52465614-52471905 (-)
CBA/J	ENSMUSG00210038560	protein coding gene	Chr13:52244963-52251187 (-)
DBA/2J	ENSMUSG00185015981	protein coding gene	Chr13:53094960-53101187 (-)
FVB/NJ	ENSMUSG00205028808	protein coding gene	Chr13:51897720-51903947 (-)
JF1/MsJ	ENSUMUG00000019615	protein coding gene	Chr13:52487150-52493368 (-)
LP/J	ENSMUSG00230032349	protein coding gene	Chr13:62437039-62443265 (-)
NOD/ShiLtJ	ENSMUSG00190021143	protein coding gene	Chr13:52137882-52144110 (-)
NZO/HlLtJ	ENSMUSG00225034215	protein coding gene	Chr13:56166738-56172965 (-)
PWK/PhJ	ENSLUMG00010022842	protein coding gene	Chr13:51359054-51365276 (-)
SPRET/EiJ	ENSMSPG00010035409	protein coding gene	Chr13:51778439-51784462 (-)
WSB/EiJ	ENSIUOG00005020079	protein coding gene	Chr13:51568848-51575076 (-)

Human Ortholog

DOK3, docking protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOK3, docking protein 3
Synonyms

DOKL
Links

HGNC:24583

NCBI Gene ID: 79930

UniProt: Q7L591
Chr Location

5q35.3; chr5:177501904-177511274 (-) GRCh38

MGI Vertebrate Homology

Dok3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOK3
Gene Tree

Dok3

Diseases

1 with human DOK3 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

7
Genomic Mutations

2 involving Dok3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. Mice for another null alelle show increased IgM antibodies and have enchanced humoral immune responses to T cell-independent type I and II antigens.

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS26548.1

Ensembl

ENSMUSG00000035711 (Evidence)
NCBI Gene

27261

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035711	Ensembl Gene Model \| MGI Sequence Detail	6066	C57BL/6J	± kb
transcript	ENSMUST00000047877	Ensembl \| MGI Sequence Detail	1546	Not Applicable
polypeptide	ENSMUSP00000046695	Ensembl \| MGI Sequence Detail	444	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006630 docking protein 3

(term hierarchy)
InterPro Domains

IPR050996 Docking Protein Family (DOK)

IPR037751 Dok1/2/3, PTB domain

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 28

Genomic 2

cDNA 26

Microarray probesets 3

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MGI:2145244

Summaries

All 58

Diseases 1

Gene Ontology 7

Phenotypes 21
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:370418 Arimura S, et al., Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine. Cancer Res Commun. 2022 Dec;2(12):1590-1600

TSS for Dok3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122716	Chr13:55677193-55677198 (-)	-87 bp
Tssr122715	Chr13:55677153-55677180 (-)	-58 bp
Tssr122714	Chr13:55676375-55676393 (-)	725 bp
Tssr122713	Chr13:55676324-55676374 (-)	760 bp
Tssr122712	Chr13:55676258-55676262 (-)	849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24