103 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoetm1Bres/Apoetm1Bres Mapk9tm1Flv/Mapk9tm1Flv involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal macrophage morphology	J:94044
	abnormal macrophage physiology	J:94044
	decreased susceptibility to atherosclerosis	J:94044
	increased macrophage derived foam cell number	J:94044
Krastm4Tyj/Kras+ Mapk8tm1Wag/Mapk8+ Mapk9tm1Mka/Mapk9tm1Mka involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	increased lung tumor incidence	J:170904
Map3k1tm1Yxia/Map3k1+ Mapk8tm1Wag/Mapk8+ Mapk9tm1Mka/Mapk9+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	early eyelid opening	J:176244
Mapk8tm1Flv/Mapk8tm1Flv Mapk9tm1.1Rjd/Mapk9tm1.1Rjd involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	decreased fibroblast proliferation	J:112737
	decreased keratinocyte migration	J:112737
	increased fibroblast apoptosis	J:112737
	increased fibroblast cell migration	J:112737
Mapk8tm1Flv/Mapk8tm1Flv Mapk9tm1Flv/Mapk9+ B6.129S-Mapk9tm1Flv Mapk8tm1Flv	abnormal epidermal layer morphology	J:93433
	abnormal eye morphology	J:83385, J:93433
	abnormal fungiform papillae morphology	J:93433
	abnormal hair follicle development	J:93433
	abnormal intestinal epithelium morphology	J:93433
	abnormal intestinal mucosa morphology	J:93433
	abnormal kidney morphology	J:83385
	abnormal lens morphology	J:83385
	abnormal lung development	J:93433
	abnormal nephron morphology	J:83385
	abnormal tongue epithelium morphology	J:93433
	abnormal tongue morphology	J:93433
	decreased hair follicle number	J:93433
	delayed intestine development	J:93433
	dilated renal tubule	J:83385
	eyelids open at birth	J:83385, J:93433
	infertility	J:93433
	pallor	J:93433
	postnatal lethality, incomplete penetrance	J:83385, J:93433
	respiratory distress	J:93433
	retina coloboma	J:83385
	small lens	J:83385
	thick pulmonary interalveolar septum	J:93433
Mapk8tm1Flv/Mapk8tm1Flv Mapk9tm1Flv/Mapk9tm1Flv involves: 129S1/Sv * 129S2/SvPas	abnormal neural tube morphology	J:54653
	decreased hindbrain apoptosis	J:54653
	dilated heart	J:54653
	embryonic lethality during organogenesis, complete penetrance	J:54653
	exencephaly	J:54653
	increased embryonic neuroepithelium apoptosis	J:54653
	increased forebrain apoptosis	J:54653
Mapk8tm1Rjd/Mapk8tm1Rjd Mapk9tm1Flv/Mapk9tm1Flv involves: 129S2/SvPas * C57BL/6J	increased fibroblast apoptosis	J:131766
Mapk8tm1Rjd/Mapk8tm1Rjd Mapk9tm1Flv/Mapk9tm1Flv Tg(Col2a1-cre)1Bhr/0 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	abnormal gait	J:277201
	abnormal intervertebral disk morphology	J:277201
	abnormal knee joint morphology	J:277201
	abnormal nucleus pulposus morphology	J:277201
	abnormal sternebra morphology	J:277201
	abnormal sternocostal joint morphology	J:277201
	abnormal tail position or orientation	J:277201
	abnormal vertebrae morphology	J:277201
	abnormal vertebral epiphyseal plate morphology	J:277201
	calcified intervertebral disk	J:277201
	decreased body size	J:277201
	distended abdomen	J:277201
	fusion of vertebral arches	J:277201
	fusion of vertebral bodies	J:277201
	ischuria	J:277201
	paraphimosis	J:277201
	premature death	J:277201
	scoliosis	J:277201
	sternebra fusion	J:277201
	vertebral fusion	J:277201
Mapk8tm1Rjd/Mapk8tm1Rjd Mapk9tm2.1Rjd/Mapk9tm2.1Rjd Lyz2tm1(cre)Ifo/Lyz2+ B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd	abnormal chemokine level	J:192551
	abnormal circulating chemokine level	J:192551
	abnormal circulating cytokine level	J:192551
	abnormal gluconeogenesis	J:192551
	abnormal glucose homeostasis	J:192551
	abnormal glycogen homeostasis	J:192551
	abnormal lipid homeostasis	J:192551
	abnormal macrophage differentiation	J:192551
	abnormal macrophage physiology	J:192551
	decreased circulating glucose level	J:192551
	decreased circulating insulin level	J:192551
	decreased inflammatory response	J:192551
	decreased lean body mass	J:192551
	decreased macrophage cell number	J:192551
	decreased macrophage cytokine production	J:192551
	decreased pancreatic beta cell proliferation	J:192551
	normal homeostasis/metabolism phenotype	J:192551
	impaired macrophage chemotaxis	J:192551
	improved glucose tolerance	J:192551
	increased insulin secretion	J:192551
	increased insulin sensitivity	J:192551
	small pancreatic islets	J:192551
Mapk8tm1Wag/Mapk8+ Mapk9tm1Mka/Mapk9+ involves: 129	abnormal T cell activation	J:78190
	decreased T cell apoptosis	J:78190
	decreased T cell proliferation	J:78190
Mapk8tm1Wag/Mapk8+ Mapk9tm1Mka/Mapk9tm1Mka involves: 129	abnormal T cell activation	J:78190
	decreased T cell apoptosis	J:78190
	decreased T cell proliferation	J:78190
Mapk8tm1Wag/Mapk8+ Mapk9tm1Mka/Mapk9tm1Mka involves: 129 * C57BL/6	normal nervous system phenotype	J:58622
Mapk8tm1Wag/Mapk8tm1Wag Mapk9tm1Mka/Mapk9+ involves: 129	abnormal T cell activation	J:78190
	decreased T cell apoptosis	J:78190
	decreased T cell proliferation	J:78190
Mapk8tm1Wag/Mapk8tm1Wag Mapk9tm1Mka/Mapk9+ involves: 129 * C57BL/6	abnormal brain development	J:58622
	abnormal cerebral hemisphere morphology	J:58622
	abnormal diencephalon morphology	J:58622
	abnormal embryonic neuroepithelial layer differentiation	J:58622
	absent brain ventricles	J:58622
	exencephaly	J:58622
	incomplete rostral neuropore closure	J:58622
	postnatal lethality, incomplete penetrance	J:58622
Mapk8tm1Wag/Mapk8tm1Wag Mapk9tm1Mka/Mapk9+ involves: 129/Sv * 129P2/OlaHsd	abnormal eyelid morphology	J:170904
Mapk8tm1Wag/Mapk8tm1Wag Mapk9tm1Mka/Mapk9tm1Mka involves: 129 * C57BL/6	abnormal embryonic neuroepithelial layer differentiation	J:58622
	abnormal forebrain development	J:58622
	decreased hindbrain apoptosis	J:58622
	decreased physiological sensitivity to xenobiotic	J:103476
	embryonic growth retardation	J:58622
	embryonic lethality during organogenesis, complete penetrance	J:58622
	incomplete rostral neuropore closure	J:58622
	increased forebrain apoptosis	J:58622
	increased hindbrain apoptosis	J:58622
Mapk9tm1Flv/Mapk9tm1Flv Tnftm2Gkl/Tnf+ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	normal immune system phenotype	J:108572
	increased apoptosis	J:108572
	small intestinal inflammation	J:108572
Mapk10tm1Flv/Mapk10tm1Flv Mapk9tm1Flv/Mapk9tm1Flv B6.129S-Mapk9tm1Flv Mapk10tm1Flv	abnormal dopamine level	J:87428
	abnormal somatic motor system morphology	J:96192
	normal behavior/neurological phenotype	J:87428
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:87428
Mapk10tm1Flv/Mapk10tm1Flv Mapk9tm1Flv/Mapk9tm1Flv involves: 129S1/Sv * 129S2/SvPas	normal nervous system phenotype	J:54653