Mapk9^tm2.1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk9^tm2.1Rjd
• Name: mitogen-activated protein kinase 9; targeted mutation 2.1, Roger J Davis
• MGI ID: MGI:5629588
• Synonyms: Jnk2^LoxP
• Gene: Mapk9 Location: Chr11:49737578-49777248 bp, + strand Genetic Position: Chr11, 29.96 cM, cytoband B1.2
• Alliance: Mapk9^tm2.1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192551
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 7 alpha. Cre-mediated recombination removed the selection cassette and left exons 6, 7beta and 7alpha floxed. (J:192551)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk9 Mutation: 33 strains or lines available

References

• Original: J:192551 Han MS, et al., JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11;339(6116):218-22
• All: 17 reference(s)