Mapk9^tm1Mka
Targeted Allele Detail

Summary

• Symbol: Mapk9^tm1Mka
• Name: mitogen-activated protein kinase 9; targeted mutation 1, Michael Karin
• MGI ID: MGI:2183601
• Synonyms: JNK2^-
• Gene: Mapk9 Location: Chr11:49737578-49777248 bp, + strand Genetic Position: Chr11, 29.96 cM, cytoband B1.2
• Alliance: Mapk9^tm1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78129
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and exon 2 were replaced with a lacZ-neo cassette via homologous recombination resulting in the in frame fusion of the first 32 amino acids with lacZ and deletion of part of the kinase domain. Northern blot analysis of homozygous mutant animals did not detect either full length or truncated transcripts. Western blot analysis of mouse embryonic fibroblasts cultured from homozygous mutants did not detect either isoform (46 kDa, 55kDa) of protein product. (J:78129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk9 Mutation: 33 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺).

References

• Original: J:78129 Sabapathy K, et al., JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol. 1999 Feb 11;9(3):116-25
• All: 34 reference(s)