Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation
(1 available);
any
Mapk9 mutation
(33 available)
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Allelic
Composition |
Mapk9tm1Mka/Mapk9tm1Mka
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Genetic
Background |
either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation
(1 available);
any
Mapk9 mutation
(33 available)
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nervous system
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• at 1 month of age in the CA1 region, field excitatory postsynaptic potentials are reduced particularly at higher stimulus intensities
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• at 1 month of age, reduced amplitude of long term potentiation in the CA1 and CA3 regions is seen after application of high frequency stimulation; however in the CA3 region post-tetanus potentiation and paired pulse facilitation are similar to wild-type
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• at 1 month of age in the CA1 region but bot in the CA3 region
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• at 1 month of age in the CA1 region, the pool of docked vesicles appears to be smaller than in wild-type mice
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• at 1 month of age in the CA1 region, paired-pulse facilitation is reduced over a wide range of interpulse intervals especially at shorter intervals
• paired pulse facilitation is not decreased in the CA3 region
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Allelic
Composition |
Mapk9tm1Mka/Mapk9tm1Mka
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Genetic
Background |
either: (involves: 129S2/SvPas) or (involves: 129S1/Sv * 129X1/SvJ) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation
(1 available);
any
Mapk9 mutation
(33 available)
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 36 hours of culture with anti-CD3 antibody homozygous T cells produce very little IL2, IL4 or IFNG unlike wild-type cells
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• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 36 hours of culture with anti-CD3 antibody homozygous T cells produce very little IL2, IL4 or IFNG unlike wild-type cells
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• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• reduced proliferation of splenic T cells after stimulation with anti-CD3 antibody with or without anti-CD28 antibody, especially at lower concentrations of antibodies
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Mka mutation
(1 available);
any
Mapk9 mutation
(33 available)
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cardiovascular system
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• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)
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• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type
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muscle
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• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)
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• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type
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cellular
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• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type
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neoplasm
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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respiratory system
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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mortality/aging
nervous system
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• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
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• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
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• the lumen of the forebrain vesicles is incompletely formed
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growth/size/body
homeostasis/metabolism
embryo
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• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
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cellular
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• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
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• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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mortality/aging
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• fewer than expected mice are found at weaning; however expected numbers are found at E12.5 to E15.5
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nervous system
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• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
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• at E15.5 in exencephalic mice, the brain tissue is expanded upward
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• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
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• at E12.5, in exencephalic mice the cerebral ventricles are absent
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• at E15.5 in exencephalic mice, the diencephalon is enlarged
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• at E15.5 in exencephalic mice, the cerebral hemispheres are displaced laterally
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• some embryos display exencephaly with absence of the entire creanial roof at E12.5
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embryo
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• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
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• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
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nervous system
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• no mice display exencephaly and no indications of increased mortality are seen
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vision/eye
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• eyes are open at birth
• however, mice exhibit normal retinal morphology
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vision/eye
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• mice exhibit an eyelid closure defect compared with wild-type mice
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Analysis Tools