Dkk1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dkk1
dickkopf WNT signaling pathway inhibitor 1
MGI:1329040

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	abnormal eye morphology	J:170646
	abnormal head morphology	J:170646
	preweaning lethality, incomplete penetrance	J:170646
Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺ either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)	abnormal head size	J:170646
	caudal body truncation	J:170646
Ctnnb1^Bfc/Ctnnb1^Bfc Dkk1^tm1Lmgd/Dkk1⁺ either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	abnormal head size	J:170646
Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺ involves: 101/H * 129 * BALB/c * C3H	abnormal head morphology	J:170646
	kinked tail	J:170646
Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6^Gw involves: 101/H * 129 * BALB/c * C3H	abnormal head morphology	J:170646
Dkk1^tm1Lmgd/Dkk1⁺ Gsc^tm2Bhr/Gsc⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased forebrain size	J:119933
Dkk1^tm1Lmgd/Dkk1⁺ Gsc^tm2Bhr/Gsc^tm2Bhr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal embryo development	J:119933
	abnormal eye development	J:119933
	decreased forebrain size	J:119933
	microcephaly	J:119933
Dkk1^tm1Lmgd/Dkk1⁺ Kremen1^tm1Dgen/Kremen1^tm1Dgen Kremen2^tm1Cni/Kremen2^tm1Cni either: B6.Cg-Kremen1^tm1Dgen Kremen2^tm1Cni Dkk1^tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	increased bone volume	J:137914
	polydactyly	J:137914
Dkk1^tm1Lmgd/Dkk1^tm1Lmgd Sfrp5^tm1Shwl/Sfrp5^tm1Shwl involves: 129 * CD-1	abnormal anterior head development	J:117057
	normal embryo phenotype	J:117057
	perinatal lethality, complete penetrance	J:117057
Dkk1^tm1Sia/Dkk1^tm1Sia Sfrp1^tm1Aksh/Sfrp1^tm1Aksh involves: 129 * C57BL/6 * CBA	incomplete somite formation	J:135313
Dkk1^tm1Sia/Dkk1^tm1Sia Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2⁺ involves: 129 * C57BL/6 * CBA	incomplete somite formation	J:135313
Dkk1^tm1Sia/Dkk1^tm1Sia Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh involves: 129 * C57BL/6 * CBA	abnormal presomitic mesoderm morphology	J:135313
	incomplete embryo turning	J:135313
	incomplete somite formation	J:135313
Gt(ROSA)26Sor^{tm1(Dkk1)Flng}/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1⁺ Tg(Msx2-cre)5Rem/0 involves: 129S4/SvJae * 129X1/SvJ	absent hindlimb	J:145305
	short forelimb	J:145305

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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