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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Aim2tm1.2Arte/Aim2tm1.2Arte
Dnase2atm1Osa/Dnase2atm1Osa
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129 * BALB/c * C57BL/6 * C57BL/6J
abnormal spleen morphology J:238323
enlarged spleen J:238323
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating tumor necrosis factor level J:238323
increased spleen weight J:238323
rheumatoid arthritis J:238323
Dnase2atm1Osa/Dnase2atm1Osa
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
abnormal blood homeostasis J:114982
abnormal cytokine level J:114982
abnormal macrophage morphology J:114982
abnormal spleen morphology J:238323
anemia J:114982
enlarged spleen J:114982, J:238323
increased anti-double stranded DNA antibody level J:114982
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating interleukin-18 level J:114982
increased circulating tumor necrosis factor level J:114982, J:238323
increased spleen red pulp amount J:114982
increased spleen weight J:238323
joint inflammation J:114982, J:238323
postnatal growth retardation J:114982
rheumatoid arthritis J:114982, J:238323
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
MRL.Cg-Ifnar1tm1Agt Faslpr
enlarged lymph nodes J:92084
glomerulonephritis J:92084
increased anti-nuclear antigen antibody level J:92084
increased autoantibody level J:92084
increased IgA level J:92084
increased IgG2b level J:92084
increased IgG3 level J:92084
increased IgG level J:92084
increased IgM level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
Ifngr1tm1Agt/Ifngr1tm1Agt
MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr
decreased anti-nuclear antigen antibody level J:92084
decreased autoantibody level J:92084
decreased IgG level J:92084
decreased susceptibility to systemic lupus erythematosus J:92084
glomerulonephritis J:92084
increased IgG level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
small lymph nodes J:92084
Ifih1Rgsc422/Ifih1+
Ifnar1tm1Agt/Ifnar1+
involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl
glomerulonephritis J:209917
Ifnar1tm1Agt/Ifnar1tm1Agt
Ifngr1tm1Agt/Ifngr1tm1Agt
involves: 129S2/SvPas * 129S7/SvEvBrd
abnormal immunoglobulin level J:101427
increased susceptibility to viral infection J:81243, J:101427
increased susceptibility to viral infection induced morbidity/mortality J:115139
Ifnar1tm1Agt/Ifnar1tm1Agt
Irf2tm1Mak/Irf2tm1Mak
involves: 129S2/SvPas * C57BL/6
abnormal skin condition J:66034
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88+
B6.129-Myd88tm1Aki Ifnar1tm1Agt
increased susceptibility to parasitic infection J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
B6.129-Myd88tm1Aki Ifnar1tm1Agt
increased susceptibility to parasitic infection J:140485
increased susceptibility to parasitic infection induced morbidity/mortality J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal leukocyte migration J:171379
Ifnar1tm1Agt/Ifnar1tm1Agt
Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
involves: 129S2/SvPas * C57BL/6N
decreased fetal size J:186986
perinatal lethality, complete penetrance J:186986
Ifnar1tm1Agt/Ifnar1tm1Agt
Slamf1tm1Oono/Slamf1tm1Oono
B6.129-Slamf1tm1Oono Ifnar1tm1Agt
abnormal lymphopoiesis J:117810
increased susceptibility to viral infection J:117810
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif
C3.Cg-Ifnar1tm1Agt Tg(H2-K1-Ifnb1)10Seif
normal reproductive system phenotype J:174828
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
decreased susceptibility to viral infection J:119783
decreased susceptibility to viral infection induced morbidity/mortality J:119783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory