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Mammalian Phenotype Ontology Annotations
Query Results - Summary
chemokine (C-C motif) receptor 2
94 phenotypes from 8 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
involves: C57BL/6
abnormal glucose homeostasis J:203000
abnormal macrophage morphology J:203000
abnormal podocyte morphology J:203000
abnormal renal glomerulus morphology J:203000
abnormal urine protein level J:203000
normal immune system phenotype J:203000
increased physiological sensitivity to xenobiotic J:203000
Not Specified
abnormal dendritic cell chemotaxis J:223508
decreased CD11b-high dendritic cell number J:223508
increased CD11b-high dendritic cell number J:223508
increased dendritic cell number J:223508
involves: BALB/cJ * C57BL/6
abnormal wound healing J:189044
decreased macrophage cell number J:189044
decreased monocyte cell number J:189044
abnormal cellular extravasation J:104744
abnormal leukocyte adhesion J:104744
altered response to myocardial infarction J:104744
involves: 129S1/Sv * ICR
abnormal spleen morphology J:111517
enlarged liver J:111517
enlarged spleen J:111517
impaired macrophage chemotaxis J:111517
increased eosinophil cell number J:111517
increased susceptibility to bacterial infection J:111517
liver inflammation J:111517
multifocal hepatic necrosis J:111517
involves: 129S4/SvJae * C57BL/6
impaired macrophage chemotaxis J:121703
decreased susceptibility to induced colitis J:161138
normal immune system phenotype J:154558
impaired leukocyte tethering or rolling J:154558
abnormal bone mineral density J:149360
abnormal bone trabecula morphology J:149360
abnormal leukocyte migration J:106738
abnormal leukocyte physiology J:122119
abnormal microglial cell physiology J:106738
abnormal osteoclast cell number J:149360
abnormal osteoclast differentiation J:149360
abnormal osteoclast physiology J:149360
abnormal trabecular bone morphology J:149360
decreased acute inflammation J:106738
decreased interferon-gamma secretion J:106738
decreased osteoclast cell number J:149360
decreased susceptibility to bone fracture J:149360
decreased tumor growth/size J:122119
increased susceptibility to viral infection J:106738
increased susceptibility to viral infection induced morbidity/mortality J:106738
increased trabecular bone thickness J:149360
increased trabecular bone volume J:149360
involves: 129S4/SvJae
abnormal monocyte morphology J:121281
involves: 129S4/SvJae * C57BL/6
abnormal cholesterol homeostasis J:81363
abnormal immune serum protein physiology J:118971
abnormal Langerhans cell physiology J:112594
abnormal lipid homeostasis J:81363
abnormal macrophage chemotaxis J:44345
abnormal microglial cell physiology J:121703
decreased airway responsiveness J:118971
decreased common myeloid progenitor cell number J:44345
decreased inflammatory response J:44345
decreased interferon-gamma secretion J:44345, J:75838
decreased interleukin-2 secretion J:44345
decreased interleukin-6 secretion J:75838
decreased splenocyte proliferation J:75838
decreased susceptibility to experimental autoimmune encephalomyelitis J:75838
decreased susceptibility to type I hypersensitivity reaction J:118971
decreased T cell proliferation J:75838
hepatic necrosis J:61542
impaired macrophage chemotaxis J:44345, J:81363, J:121703
increased circulating alanine transaminase level J:61542
increased hepatocyte apoptosis J:61542
increased interferon-gamma secretion J:61542
increased physiological sensitivity to xenobiotic J:61542
increased tumor necrosis factor secretion J:61542
liver hemorrhage J:61542
involves: 129S4/SvJae * C57BL/6J
abnormal vascular wound healing J:110790
abnormal Bruch membrane morphology J:147328
abnormal choriocapillaris morphology J:147328
abnormal conditioned taste aversion behavior J:102583
abnormal optic choroid morphology J:147328
abnormal retinal pigment epithelium morphology J:147328
alcohol aversion J:102583
choroidal neovascularization J:147328
decreased alcohol consumption J:102583
decreased macrophage cell number J:147328
increased alcohol consumption J:102583
increased fluid intake J:102583
increased IgG level J:147328
lipofuscinosis J:147328
retinal degeneration J:147328
retinal deposits J:147328
retinal outer nuclear layer degeneration J:147328
retinal photoreceptor degeneration J:147328
involves: 129P2/OlaHsd
abnormal chemokine secretion J:151874
abnormal leukocyte migration J:171379
impaired macrophage chemotaxis J:151874, J:191510
involves: 129P2/OlaHsd * BALB/c
abnormal leukocyte physiology J:162714
decreased circulating creatinine level J:162714
decreased neutrophil cell number J:162714
decreased susceptibility to kidney reperfusion injury J:162714
impaired macrophage chemotaxis J:162714
involves: 129P2/OlaHsd * C57BL/6J
abnormal cytokine secretion J:110814
decreased CD4-positive, alpha beta T cell number J:110814
decreased inflammatory response J:110814
diarrhea J:110814
increased B cell number J:110814
increased CD8-positive, alpha-beta T cell number J:110814
increased susceptibility to induced colitis J:110814
weight loss J:110814
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal wound healing J:189044
decreased macrophage cell number J:189044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory