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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Npm1
nucleophosmin 1
MGI:106184
13 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn 		abnormal bone marrow cell physiology J:272803
Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+
Npm1tm1Gsva/Npm1+
TgTn(pb-sb-GrOnc)#aGsva/0
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased acute promyelocytic leukemia incidence J:172071
increased B cell derived lymphoma incidence J:172071
increased hemangiosarcoma incidence J:172071
increased leukemia incidence J:172071
increased lymphoma incidence J:172071
premature death J:172071
Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 		abnormal apoptosis J:101353
embryonic lethality during organogenesis, complete penetrance J:101353
increased fibroblast proliferation J:101353
Npm1tm1Ppp/Npm1+
Trp53tm1Brd/Trp53tm1Brd
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		increased fibroblast proliferation J:101494
Npm1tm1Ppp/Npm1+
Tg(IghMyc)22Bri/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal tumor morphology J:101494
increased B cell derived lymphoma incidence J:101494
Npm1tm1Ppp/Npm1tm1Ppp
Trp53tm1Brd/Trp53+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		embryonic lethality, complete penetrance J:101494
Npm1tm1Ppp/Npm1tm1Ppp
Trp53tm1Brd/Trp53tm1Brd
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:101494
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory