52 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B9d2/Tgfb1tm1Flv/B9d2+ Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129S6/SvEvTac * 129X1/SvJ	abnormal enterocyte proliferation	J:169839
	abnormal T cell differentiation	J:169839
	cachexia	J:169839
	colitis	J:169839
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:169839
	decreased T-helper 17 cell number	J:169839
	increased regulatory T cell number	J:169839
	increased T-helper 1 cell number	J:169839
	liver inflammation	J:169839
	lung inflammation	J:169839
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129S6/SvEvTac * 129X1/SvJ	abnormal enterocyte proliferation	J:169839
	abnormal T cell differentiation	J:169839
	cachexia	J:169839
	colitis	J:169839
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:169839
	decreased T-helper 17 cell number	J:169839
	increased regulatory T cell number	J:169839
	increased T-helper 1 cell number	J:169839
	liver inflammation	J:169839
	lung inflammation	J:169839
Card11tm1.1Litt/Card11tm1.1Litt Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129P2/OlaHsd * 129X1/SvJ	abnormal T cell activation	J:180410
	normal immune system phenotype	J:180410
	respiratory system inflammation	J:180410
	normal respiratory system phenotype	J:180410
Cd4tm1Nik/Cd4tm1Nik Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129X1/SvJ	abnormal regulatory T cell physiology	J:152472
Elavl1tm1.1Atas/Elavl1tm1.1Atas Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129X1/SvJ * C57BL/6	decreased susceptibility to experimental autoimmune encephalomyelitis	J:207013
	decreased T cell proliferation	J:207013
	decreased T-helper 17 cell number	J:207013
Fyntm1Sor/Fyntm1Sor Lcktm1Litt/Lcktm1.1Litt Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal regulatory T cell physiology	J:152472
	decreased regulatory T cell number	J:152472
	decreased T cell proliferation	J:152472
	enlarged lymph nodes	J:152472
	increased regulatory T cell number	J:152472
	increased T cell number	J:152472
Lcktm1Litt/Lcktm1.1Litt Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129X1/SvJ	abnormal regulatory T cell physiology	J:152472
	decreased regulatory T cell number	J:152472
	decreased T cell proliferation	J:152472
	enlarged lymph nodes	J:152472
	increased regulatory T cell number	J:152472
	increased T cell number	J:152472
Nbr1tm1.1Jmos/Nbr1tm1.1Jmos Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129X1/SvJ * C57BL/6J	abnormal T-helper 1 cell differentiation	J:165438
	abnormal T-helper 2 cell differentiation	J:165438
	decreased inflammatory response	J:165438
	decreased interferon-gamma secretion	J:165438
	decreased interleukin-4 secretion	J:165438
	decreased interleukin-5 secretion	J:165438
	decreased interleukin-13 secretion	J:165438
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw Rag2tm1Fwa/Rag2tm1Fwa Tnfrsf4tm2(cre)Nik/Tnfrsf4+ Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ involves: 129S/SvEv * 129X1/SvJ * C57BL/6	abnormal keratinocyte differentiation	J:226194
	dermatitis	J:226194
	epidermal hyperplasia	J:226194
	premature death	J:226194
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw Tnfrsf4tm2(cre)Nik/Tnfrsf4+ Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ involves: 129X1/SvJ * C57BL/6	abnormal hypodermis fat layer morphology	J:226194
	abnormal keratinocyte differentiation	J:226194
	abnormal regulatory T cell number	J:226194
	abnormal T cell physiology	J:226194
	cachexia	J:226194
	dermatitis	J:226194
	enlarged lymph nodes	J:226194
	enlarged spleen	J:226194
	epidermal hyperplasia	J:226194
	hair follicle degeneration	J:226194
	hyperkeratosis	J:226194
	impaired skin barrier function	J:226194
	premature death	J:226194
	premature hair loss	J:226194
	scaly skin	J:226194
	skin fibrosis	J:226194
	skin hyperplasia	J:226194
	skin lesions	J:226194
	thick skin	J:226194
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	abnormal humoral immune response	J:164283
	decreased germinal center B cell number	J:164283
	decreased IgG1 level	J:164283
	decreased spleen germinal center number	J:164283
	decreased T follicular helper cell number	J:164283
Ptentm2.1Ppp/Ptentm2.1Ppp Tnfrsf4tm2(cre)Nik/Tnfrsf4+ involves: 129S1/Sv * 129X1/SvJ	increased germinal center B cell number	J:164283
	increased IgG1 level	J:164283
	increased T follicular helper cell number	J:164283
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tnfrsf4tm2(cre)Nik/Tnfrsf4+ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 involves: 129 * C57BL/6 * NOD * SJL	normal immune system phenotype	J:196160
	increased susceptibility to autoimmune diabetes	J:196160