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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Six2
sine oculis-related homeobox 2
MGI:102778
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdc42tm1Brak/Cdc42tm1Brak
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * C57BL/6J
abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney papilla morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266
Ctdnep1tm3Ryn/Ctdnep1tm3Ryn
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129X1/SvJ * C57BL/6 * C57BL/6J
decreased kidney apoptosis J:205755
Ctdnep1tm3Ryn/Ctdnep1tm3Ryn
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * C57BL/6 * C57BL/6J
abnormal kidney morphology J:205755
abnormal nephron morphology J:205755
abnormal proximal convoluted tubule morphology J:205755
decreased kidney weight J:205755
premature death J:205755
renal glomerulus atrophy J:205755
small kidney J:205755
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129S4/SvJaeSor * C57BL/6J
abnormal renal tubule morphology J:185844
Gt(ROSA)26Sortm1(Sall1)Ryn/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1
no abnormal phenotype detected J:162052
Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
abnormal kidney development J:185844
abnormal metanephric ureteric bud development J:185844
abnormal nephrogenic zone morphology J:185844
absent metanephric mesenchyme J:185844
dilated proximal convoluted tubules J:185844
dilated renal tubules J:185844
impaired branching involved in ureteric bud morphogenesis J:185844
neonatal lethality, complete penetrance J:185844
renal glomerulus cysts J:185844
small kidney J:185844
Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc
involves: 129/Sv * 129X1/SvJ * C57BL/6J
abnormal kidney development J:148455
delayed kidney development J:148455
Six2tm1Gco/Six2tm1Gco
Wnt9btm1.1Amc/Wnt9btm1.1Amc
involves: 129X1/SvJ * C57BL/6J * NMRI
abnormal kidney development J:148455
Wasltm2Sbs/Wasltm2Sbs
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * C57BL/6J
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
renal hypoplasia J:195266
Wwtr1tm1Hmc/Wwtr1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
kidney cysts J:195266
kidney hemorrhage J:195266
Wwtr1tm1Hmc/Wwtr1tm1Hmc
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl
abnormal kidney development J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
kidney cysts J:195266
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney medulla morphology J:195266
abnormal kidney papilla morphology J:195266
abnormal loop of Henle morphology J:195266
abnormal metanephros morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
abnormal renal glomerulus morphology J:195266
abnormal renal tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
impaired branching involved in ureteric bud morphogenesis J:195266
podocyte foot process effacement J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory