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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Vav2
vav 2 oncogene
MGI:102718
67 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
involves: 129S1/Sv * 129S2/SvPas
decreased B cell proliferation J:86654
decreased double-negative T cell number J:86654
decreased double-positive T cell number J:86654
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:86654
decreased T cell number J:86654
decreased T cell proliferation J:86654
decreased thymocyte number J:86654
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac
abnormal macrophage physiology J:145345
abnormal neutrophil physiology J:145345
abnormal NK cell physiology J:187430
decreased interleukin-10 secretion J:145345
decreased tumor necrosis factor secretion J:145345
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6
abnormal B cell physiology J:86654
abnormal enterocyte morphology J:146174
abnormal humoral immune response J:86654
abnormal T cell physiology J:86654
arrested B cell differentiation J:86654
arrested T cell differentiation J:86654
decreased B cell proliferation J:86654
decreased double-positive T cell number J:86654
decreased follicular B cell number J:86654
decreased IgG1 level J:86654
decreased IgG2b level J:86654
decreased IgG3 level J:86654
decreased IgM level J:86654
decreased immunoglobulin level J:86654
decreased interferon-gamma secretion J:86654
decreased interleukin-2 secretion J:86654
decreased marginal zone B cell number J:86654
decreased mature B cell number J:86654
decreased single-positive T cell number J:86654
decreased T cell number J:86654
decreased T cell proliferation J:86654
decreased thymocyte number J:86654
decreased transitional stage T2 B cell number J:86654
impaired wound healing J:146174
increased immature B cell number J:86654
increased transitional stage T1 B cell number J:86654
intestinal ulcer J:146174
Vav1tm1Tyb/Vav1tm1Tyb
Vav2tm1Tnr/Vav2tm1Tnr
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal B cell physiology J:69807
decreased B cell number J:69807
decreased B cell proliferation J:69807
decreased CD4-positive, alpha beta T cell number J:69807
decreased CD8-positive, alpha-beta T cell number J:69807
decreased follicular B cell number J:69807
decreased immature B cell number J:69807
decreased mature B cell number J:69807
Vav1tm2Bbd/Vav1tm2Bbd
Vav2tm1Kdf/Vav2tm1Kdf
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal B cell activation J:69806
abnormal B cell differentiation J:69806
abnormal lymph node cell ratio J:69806
abnormal splenic cell ratio J:69806
abnormal T cell differentiation J:69806
decreased B cell number J:69806
decreased B cell proliferation J:69806
decreased B-1 B cell number J:69806
decreased CD8-positive, alpha-beta T cell number J:69806
decreased IgG1 level J:69806
decreased IgG2b level J:69806
decreased IgG3 level J:69806
decreased IgM level J:69806
decreased immunoglobulin level J:69806
decreased mature B cell number J:69806
decreased T cell number J:69806
thymus hypoplasia J:69806
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
B6.129S-Vav2tm1Kdf Vav3tm1Swat
abnormal eye morphology J:158008
abnormal iridocorneal angle J:158008
anterior iris synechia J:158008
buphthalmos J:158008
decreased physiological sensitivity to xenobiotic J:158008
increased physiological sensitivity to xenobiotic J:158008
ocular hypertension J:158008
optic nerve cupping J:158008
retinal ganglion cell degeneration J:158008
Vav2tm1Kdf/Vav2tm1Kdf
Vav3tm1Swat/Vav3tm1Swat
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
normal immune system phenotype J:86654
Vav2tm1Tnr/Vav2tm1Tnr
Vav3tm1Swat/Vav3tm1Swat
involves: 129P2/OlaHsd * 129S6/SvEvTac
abnormal cell adhesion J:110334
abnormal vascular endothelial cell migration J:110334
abnormal vascular endothelial cell physiology J:110334
decreased angiogenesis J:110334
Vav2tm1Tnr/Vav2tm1Tnr
Vav3tm1Swat/Vav3tm1Swat
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
abnormal axon guidance J:98310
abnormal sensory neuron innervation pattern J:98310
Vav2tm1Tnr/Vav2tm1Tnr
Vav3tm1Xrb/Vav3tm1Xrb
involves: 129P2/OlaHsd
increased angiotensin I-converting enzyme activity J:124056
increased circulating adrenaline level J:124056
increased circulating noradrenaline level J:124056
increased dopamine level J:124056
increased heart rate J:124056
increased mean systemic arterial blood pressure J:124056
increased renin activity J:124056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory