67 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Vav1tm1Tyb/Vav1tm1Tyb Vav2tm1Kdf/Vav2tm1Kdf involves: 129S1/Sv * 129S2/SvPas	decreased B cell proliferation	J:86654
	decreased double-negative T cell number	J:86654
	decreased double-positive T cell number	J:86654
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:86654
	decreased T cell number	J:86654
	decreased T cell proliferation	J:86654
	decreased thymocyte number	J:86654
Vav1tm1Tyb/Vav1tm1Tyb Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac	abnormal macrophage physiology	J:145345
	abnormal neutrophil physiology	J:145345
	abnormal NK cell physiology	J:187430
	decreased interleukin-10 secretion	J:145345
	decreased tumor necrosis factor secretion	J:145345
Vav1tm1Tyb/Vav1tm1Tyb Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6	abnormal B cell physiology	J:86654
	abnormal enterocyte morphology	J:146174
	abnormal humoral immune response	J:86654
	abnormal T cell physiology	J:86654
	arrested B cell differentiation	J:86654
	arrested T cell differentiation	J:86654
	decreased B cell proliferation	J:86654
	decreased double-positive T cell number	J:86654
	decreased follicular B cell number	J:86654
	decreased IgG1 level	J:86654
	decreased IgG2b level	J:86654
	decreased IgG3 level	J:86654
	decreased IgM level	J:86654
	decreased immunoglobulin level	J:86654
	decreased interferon-gamma secretion	J:86654
	decreased interleukin-2 secretion	J:86654
	decreased marginal zone B cell number	J:86654
	decreased mature B cell number	J:86654
	decreased single-positive T cell number	J:86654
	decreased T cell number	J:86654
	decreased T cell proliferation	J:86654
	decreased thymocyte number	J:86654
	decreased transitional stage T2 B cell number	J:86654
	impaired wound healing	J:146174
	increased immature B cell number	J:86654
	increased transitional stage T1 B cell number	J:86654
	intestinal ulcer	J:146174
Vav1tm1Tyb/Vav1tm1Tyb Vav2tm1Tnr/Vav2tm1Tnr involves: 129P2/OlaHsd * 129S2/SvPas	abnormal B cell physiology	J:69807
	decreased B cell number	J:69807
	decreased B cell proliferation	J:69807
	decreased CD4-positive, alpha-beta T cell number	J:69807
	decreased CD8-positive, alpha-beta T cell number	J:69807
	decreased follicular B cell number	J:69807
	decreased immature B cell number	J:69807
	decreased mature B cell number	J:69807
Vav1tm2Bbd/Vav1tm2Bbd Vav2tm1Kdf/Vav2tm1Kdf involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal B cell activation	J:69806
	abnormal B cell differentiation	J:69806
	abnormal lymph node cell ratio	J:69806
	abnormal splenic cell ratio	J:69806
	abnormal T cell differentiation	J:69806
	decreased B cell number	J:69806
	decreased B cell proliferation	J:69806
	decreased B-1 B cell number	J:69806
	decreased CD8-positive, alpha-beta T cell number	J:69806
	decreased IgG1 level	J:69806
	decreased IgG2b level	J:69806
	decreased IgG3 level	J:69806
	decreased IgM level	J:69806
	decreased immunoglobulin level	J:69806
	decreased mature B cell number	J:69806
	decreased T cell number	J:69806
	thymus hypoplasia	J:69806
Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat B6.129S-Vav2tm1Kdf Vav3tm1Swat	abnormal eye morphology	J:158008
	abnormal iridocorneal angle	J:158008
	anterior iris synechia	J:158008
	buphthalmos	J:158008
	decreased physiological sensitivity to xenobiotic	J:158008
	increased physiological sensitivity to xenobiotic	J:158008
	ocular hypertension	J:158008
	optic nerve cupping	J:158008
	retina ganglion cell degeneration	J:158008
Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	normal immune system phenotype	J:86654
Vav2tm1Tnr/Vav2tm1Tnr Vav3tm1Swat/Vav3tm1Swat involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal cell adhesion	J:110334
	abnormal vascular endothelial cell migration	J:110334
	abnormal vascular endothelial cell physiology	J:110334
	decreased angiogenesis	J:110334
Vav2tm1Tnr/Vav2tm1Tnr Vav3tm1Swat/Vav3tm1Swat involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	abnormal axon guidance	J:98310
	abnormal sensory neuron innervation pattern	J:98310
Vav2tm1Tnr/Vav2tm1Tnr Vav3tm1Xrb/Vav3tm1Xrb involves: 129P2/OlaHsd	increased angiotensin I-converting enzyme activity	J:124056
	increased circulating adrenaline level	J:124056
	increased circulating noradrenaline level	J:124056
	increased dopamine level	J:124056
	increased heart rate	J:124056
	increased mean systemic arterial blood pressure	J:124056
	increased renin activity	J:124056