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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc12a2
solute carrier family 12, member 2
MGI:101924
89 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc12a2em1Dlp/Slc12a2+
involves: C57BL/6J * DBA/2J 		abnormal digestive system physiology J:285398
abnormal exocytosis J:285398
abnormal feces composition J:285398
abnormal intestinal mucosa morphology J:285398
abnormal intestine physiology J:285398
decreased intestinal mucosa thickness J:285398
increased susceptibility to bacterial infection J:285398
Slc12a2em1Dlp/Slc12a2+
Not Specified 		normal homeostasis/metabolism phenotype J:264250
Slc12a2em1Dlp/Slc12a2em1Dlp
B6.Cg-Slc12a2em1Dlp 		abnormal intestine morphology J:285398
gastrointestinal hemorrhage J:285398
premature death J:285398
preweaning lethality, incomplete penetrance J:285398
Slc12a2em1Dlp/Slc12a2em1Dlp
involves: C57BL/6J * DBA/2J 		abnormal digestive system physiology J:285398
abnormal exocytosis J:285398
abnormal feces composition J:285398
abnormal intestinal goblet cell physiology J:285398
abnormal intestinal mucosa morphology J:285398
abnormal intestinal transit time J:285398
abnormal intestine physiology J:285398
abnormal mucous gland physiology J:285398
decreased colon goblet cell number J:285398
decreased intestinal mucosa thickness J:285398
increased lymphocyte cell number J:285398
increased susceptibility to bacterial infection J:285398
large intestinal inflammation J:285398
premature death J:285398
Slc12a2K842*/Slc12a2K842*
involves: FVB/N 		abnormal crista ampullaris morphology J:201156
abnormal inner ear morphology J:201156
circling J:201156
collapsed Reissner membrane J:201156
deafness J:201156
head tossing J:201156
hyperactivity J:201156
impaired balance J:201156
utricular degeneration J:201156
vestibular saccular degeneration J:201156
Slc12a2mpc246H/Slc12a2mpc246H
involves: BALB/c * C3H/HeH * C57BL/6J 		abnormal inner ear vestibule morphology J:234901
deafness J:234901
Slc12a2sy-ns/Slc12a2sy-ns
involves: C57BL/6 * MK/ReJ 		abnormal ear morphology J:56631
abnormal interdental cell morphology J:56631
abnormal membranous labyrinth morphology J:56631
abnormal organ of Corti supporting cell morphology J:56631
abnormal semicircular canal morphology J:56631
abnormal stria vascularis morphology J:56631
abnormal sulcus ampullaris morphology J:56631
absent cochlear hair cells J:56631
circling J:50578
collapsed Reissner membrane J:56631
deafness J:50578
head bobbing J:50578
increased or absent threshold for auditory brainstem response J:50578
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Emx1tm1(cre)Krj/Emx1+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		normal behavior/neurological phenotype J:201156
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
En1tm2(cre)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal behavior/neurological phenotype J:201156
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal crista ampullaris morphology J:201156
abnormal inner ear morphology J:201156
circling J:201156
collapsed Reissner membrane J:201156
hyperactivity J:201156
utricular degeneration J:201156
vestibular saccular degeneration J:201156
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Tbx1tm6(cre)Bld/Tbx1+
Tg(Pax2-cre)1Akg/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal crista ampullaris morphology J:201156
abnormal inner ear morphology J:201156
circling J:201156
collapsed Reissner membrane J:201156
hyperactivity J:201156
utricular degeneration J:201156
vestibular saccular degeneration J:201156
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		normal behavior/neurological phenotype J:201156
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Tg(Nes-cre)1Atp/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		normal behavior/neurological phenotype J:201156
Slc12a2tm1Bhk/Slc12a2tm1Bhk
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J 		abnormal hearing physiology J:60671
abnormal spermatid morphology J:60671
abnormal spermatogenesis J:60671
absent startle reflex J:60671
ataxia J:60671
azoospermia J:60671
decreased body size J:60671
decreased body weight J:60671
decreased male germ cell number J:60671
head tossing J:60671
hyperactivity J:60671
male infertility J:60671
postnatal growth retardation J:60671
reduced female fertility J:60671
reduced male mating frequency J:60671
small testis J:60671
unidirectional circling J:60671
Slc12a2tm1Dlp/Slc12a2tm1Dlp
involves: 129S6/SvEvTac * C57BL/6 		abnormal cochlea morphology J:55514
abnormal motor coordination/balance J:55514
abnormal organ of Corti morphology J:55514
absent cochlear hair cells J:55514
absent organ of Corti supporting cells J:55514
absent startle reflex J:55514
circling J:55514
collapsed Reissner membrane J:55514
deafness J:55514
head bobbing J:55514
hyperactivity J:55514
postnatal growth retardation J:55514
weakness J:55514
Slc12a2tm1Ges/Slc12a2tm1Ges
Not Specified 		abnormal auditory brainstem response J:57651
abnormal colon morphology J:57651
abnormal cranial ganglia morphology J:57651
abnormal ear physiology J:57651
abnormal intestine morphology J:57651
abnormal membranous labyrinth morphology J:57651
abnormal motor coordination/balance J:57651
abnormal scala media morphology J:57651
abnormal stria vascularis morphology J:57651
abnormal strial marginal cell morphology J:57651
abnormal tectorial membrane morphology J:57651
absent pinna reflex J:57651
absent tunnel of Corti J:57651
circling J:57651
coiled cecum J:57651
collapsed Reissner membrane J:57651
deafness J:57651
decreased body size J:57651
decreased cochlear inner hair cell number J:57651
decreased cochlear outer hair cell number J:57651
decreased salivation J:64324
decreased systemic arterial blood pressure J:57651
decreased total body fat amount J:57651
head bobbing J:57651
head tilt J:57651
postnatal growth retardation J:57651
postnatal lethality, incomplete penetrance J:57651
remittent intestinal hemorrhage J:57651
small intestinal prolapse J:57651
spinning J:57651
Slc12a2tm2Bhk/Slc12a2tm2Bhk
involves: 129P2/OlaHsd * C57BL/6 		impaired hearing J:143314
increased or absent threshold for auditory brainstem response J:143314
Slc12a2tm2Bhk/Slc12a2tm2Bhk
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J 		abnormal Boettcher cell morphology J:106383
abnormal cochlear inner hair cell morphology J:106383
abnormal hearing physiology J:60671
abnormal interdental cell morphology J:106383
abnormal maternal nurturing J:60671
abnormal membranous labyrinth morphology J:106383
abnormal organ of Corti morphology J:106383
abnormal organ of Corti supporting cell morphology J:106383
abnormal patterning of the organ of Corti J:106383
abnormal Reissner membrane morphology J:106383
abnormal spermatid morphology J:60671
abnormal spermatogenesis J:60671
abnormal strial marginal cell morphology J:106383
abnormal tectorial membrane morphology J:106383
abnormal type II spiral ligament fibrocytes J:106383
abnormal type IV spiral ligament fibrocytes J:106383
absent scala media J:106383
absent startle reflex J:60671
absent tunnel of Corti J:106383
ataxia J:60671
azoospermia J:60671
collapsed Reissner membrane J:106383
decreased body size J:60671
decreased body weight J:60671
decreased male germ cell number J:60671
head tossing J:60671
hyperactivity J:60671
male infertility J:60671
reduced female fertility J:60671
reduced male mating frequency J:60671
small testis J:60671
unidirectional circling J:60671
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory