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Targeted Allele Detail
Symbol: Tbx1tm6(cre)Bld
Name: T-box 1; targeted mutation 6, Antonio Baldini
MGI ID: MGI:3757964
Synonyms: Tbx1Cre
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm6(cre)Bld page
Failure of inner ear morphogenesis in Tbx1tm1Bld/Tbx1tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1tm6(cre)Bld/Tbx1tm1Bld Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/ Gt(ROSA)26Sor+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:125024
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Tbx1tm6(cre)Bld expression driven by 1 gene
Mutation detailsAn IRES-cre cassette was inserted into exon 5. Expression of cre is induced in head mesoderm and mesoderm located dorsally to the cardiac cresent at E75. to E8.5, most mesoderm dorsal and lateral to the pharynx and head mesoderm at 4- and 6-somite stage, and mesoderm that virtually surrounds the pharynx at 8-somite stage in a pattern that is similar to Tbx1 expression. Author states that this is a null allele. (J:125024)
 Tissue activity of this recombinase allele
Driver: Tbx1 (mouse)
Summary of all recombinase alleles driven by Tbx1.

View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  35 strains or lines available
Original:  J:125024 Huynh T, et al., A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis. 2007 Jul;45(7):470-5
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory