Tbx1tm6(cre)Bld
Targeted Allele Detail
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Symbol: |
Tbx1tm6(cre)Bld |
Name: |
T-box 1; targeted mutation 6, Antonio Baldini |
MGI ID: |
MGI:3757964 |
Synonyms: |
Tbx1Cre |
Gene: |
Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
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Alliance: |
Tbx1tm6(cre)Bld page
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Failure of inner ear morphogenesis in Tbx1tm1Bld/Tbx1tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1tm6(cre)Bld/Tbx1tm1Bld Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/ Gt(ROSA)26Sor+ mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:125024
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Tbx1tm6(cre)Bld expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Tbx1 (MGI:98493) |
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Mutation details: An IRES-cre cassette was inserted into exon 5. Expression of cre is induced in head mesoderm and mesoderm located dorsally to the cardiac cresent at E75. to E8.5, most mesoderm dorsal and lateral to the pharynx and head mesoderm at 4- and 6-somite stage, and mesoderm that virtually surrounds the pharynx at 8-somite stage in a pattern that is similar to Tbx1 expression. Author states that this is a null allele.
(J:125024)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Tbx1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:125024 Huynh T, et al., A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis. 2007 Jul;45(7):470-5 |
All: |
24 reference(s) |
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