All Phenotypes Tbx1<tm6(cre)Bld> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx1^tm6(cre)Bld
targeted mutation 6, Antonio Baldini
MGI:3757964

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx1^tm6(cre)Bld/Tbx1⁺	involves: C57BL/6J	MGI:5583884
ht2	Tbx1^tm1Bld/Tbx1^tm6(cre)Bld	involves: 129S7/SvEvBrd	MGI:5551756
cn3	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm6(cre)Bld/Tbx1⁺	involves: 129 * C57BL/6 * SJL	MGI:5551752
cn4	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm6(cre)Bld/Tbx1⁺	involves: 129 * C57BL/6 * SJL	MGI:5551753
cn5	Slc12a2^tm1.1Jheb/Slc12a2^tm1.1Jheb Tbx1^tm6(cre)Bld/Tbx1⁺ Tg(Pax2-cre)1Akg/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5538349
cn6	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx1^tm3.1Bld/Tbx1^tm6(cre)Bld	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:4453458
cn7	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm1Bld/Tbx1^tm6(cre)Bld	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5551755
cn8	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm1Bld/Tbx1^tm6(cre)Bld	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5551754
cn9	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Tbx1^tm6(cre)Bld/Tbx1⁺	involves: C57BL/6N	MGI:7543765
cx10	Smad7^{Gt(YHC053)Byg}/Smad7⁺ Tbx1^tm6(cre)Bld/Tbx1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:5583882

Allelic Composition	Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:212881 )

• 47% of E15.5 fetuses show great vessel defects

Allelic Composition	Tbx1^tm1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in all mice

ventricular septal defect ( J:204435 )

• in all mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:204435 )

N	• mice exhibit normal heart development at E14.5

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:204435 )

N	• mice do not exhibit any morphological defects in the inner ear

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Heart development defects in Tbx1^tm6(cre)Bld/Tbx1⁺ Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mice

mortality/aging

postnatal lethality, complete penetrance ( J:204435 )

• no mice are present at P10

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in 2 of 5 mice

double outlet right ventricle ( J:204435 )

• in 3 of 5 mice

ventricular septal defect ( J:204435 )

• in all mice

Allelic Composition	Slc12a2^tm1.1Jheb/Slc12a2^tm1.1Jheb Tbx1^tm6(cre)Bld/Tbx1⁺ Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2^tm1.1Jheb mutation (0 available); any Slc12a2 mutation (58 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)
Tg(Pax2-cre)1Akg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:201156 )

circling ( J:201156 )

hearing/vestibular/ear

abnormal inner ear morphology ( J:201156 )

• collapse of the membranes of the vestibular compartments

collapsed Reissner membrane ( J:201156 )

abnormal crista ampullaris morphology ( J:201156 )

• cristae degeneration

utricular degeneration ( J:201156 )

vestibular saccular degeneration ( J:201156 )

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx1^tm3.1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm3.1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:159824 )

• abnormal lymphatic vessels fail to extend into distal mesentery unlike in wild-type mice

• between E15.5 and E16.5, lymphatic vessels are almost completely lost unlike in wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} can patially rescue heart phenotypes in Tbx1^tm6(cre)Bld/Tbx1^tm1Bld mice

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in 5 of 6 mice

double outlet right ventricle ( J:204435 )

• in 1 of 6 mice

ventricular septal defect ( J:204435 )

• in 5 of 6 mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Failure of inner ear morphogenesis in Tbx1^tm1Bld/Tbx1^tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1^tm6(cre)Bld/Tbx1^tm1Bld Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/ Gt(ROSA)26Sor⁺ mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:204435 )

N	• recovery of the anterior and posterior semicircular canals compared with null mice

abnormal cochlea morphology ( J:204435 )

• partial rescue with null mice

abnormal vestibular saccule morphology ( J:204435 )

• partial rescue with null mice

cardiovascular system

double outlet right ventricle ( J:204435 )

• in half of mice

ventricular septal defect ( J:204435 )

• in all mice

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Setd5 mutation (120 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:314464 )

N	• at E15.5, hearts show no great vessel defects; outflow tract septation is largely normal and the atrial septum and atrioventricular valves are intact

Allelic Composition	Smad7^{Gt(YHC053)Byg}/Smad7⁺ Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7^{Gt(YHC053)Byg} mutation (1 available); any Smad7 mutation (53 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:212881 )

• 52% of E15.5 fetuses show great vessel defects

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