Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Bernice E Morrow
• MGI ID: MGI:5551717
• Synonyms: Tbx1-GFP^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} page

Thymic aplasia, nasal malformations, and eye, pharyngeal and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ mice and microcephaly, ocular and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204435
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tbx1 (MGI:98493)

• Mutation details: The targeting construct inserted into the locus a splice acceptor, floxed neomycin resistance cassette with three poly adenylation sequences and a fusion of Tbx1 with GFP. (J:204435)

Generation of the Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} allele

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:204435 Freyer L, et al., Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol. 2013 Aug 23;13(1):33
• All: 4 reference(s)