Slc12a2^tm1Dlp
Targeted Allele Detail

Summary

• Symbol: Slc12a2^tm1Dlp
• Name: solute carrier family 12, member 2; targeted mutation 1, Eric Delpire
• MGI ID: MGI:1935225
• Synonyms: NKCC1^-
• Gene: Slc12a2 Location: Chr18:58011750-58079893 bp, + strand Genetic Position: Chr18, 32.15 cM
• Alliance: Slc12a2^tm1Dlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55514
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 9 with a beta-galactosidase/neomycin cassette. Inactivation of the protein transporter activity was demonstrated by measuring bumetanide-sensitive 86-Rb uptake in isolated erythrocytes. No iostopic uptake was seen in erythrocytes derived from homozygous mutant embryos. (J:55514)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a2 Mutation: 58 strains or lines available

References

• Original: J:55514 Delpire E, et al., Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nat Genet. 1999 Jun;22(2):192-5
• All: 7 reference(s)