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Cisd2 Gene Detail
Summary
  • Symbol
    Cisd2
  • Name
    CDGSH iron sulfur domain 2
  • Synonyms
    1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Zcd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914256
    NCBI Gene: 67006
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135112173-135129194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 62.55 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914256
 protein coding gene Chr3:135112173-135129686 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027906
 protein coding gene Chr3:138282870-138299630 (-)
A/J MGP_AJ_G0027864
 protein coding gene Chr3:133429713-133447630 (-)
AKR/J MGP_AKRJ_G0027829
 protein coding gene Chr3:136964111-136981629 (-)
BALB/cJ MGP_BALBcJ_G0027877
 protein coding gene Chr3:133287402-133304273 (-)
C3H/HeJ MGP_C3HHeJ_G0027606
 protein coding gene Chr3:137302078-137320163 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028320
 protein coding gene Chr3:143122091-143140486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025658
 protein coding gene Chr3:128670941-128688457 (-)
CAST/EiJ MGP_CASTEiJ_G0027062
 protein coding gene Chr3:137034707-137051462 (-)
CBA/J MGP_CBAJ_G0027582
 protein coding gene Chr3:147962992-147981098 (-)
DBA/2J MGP_DBA2J_G0027722
 protein coding gene Chr3:132594791-132611652 (-)
FVB/NJ MGP_FVBNJ_G0027689
 protein coding gene Chr3:130083868-130101213 (-)
LP/J MGP_LPJ_G0027832
 protein coding gene Chr3:139724254-139741037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027720
 protein coding gene Chr3:156084768-156102514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028378
 protein coding gene Chr3:136501707-136519882 (-)
PWK/PhJ MGP_PWKPhJ_G0026786
 protein coding gene Chr3:132308453-132325237 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026612
 protein coding gene Chr3:134579386-134596070 (-)
WSB/EiJ MGP_WSBEiJ_G0027141
 protein coding gene Chr3:137290117-137306916 (-)



Homology
more
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
  • Synonyms
    ERIS, Miner1, NAF-1, WFS2, ZCD2
  • Links
    NCBI Gene ID: 493856
    neXtProt AC: NX_Q8N5K1
    UniProt: Q8N5K1

  • Chr Location
    4q24; chr4:102868974-102892807 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CISD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    40 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    27
  • cDNA Data
    94
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67006 NCBI Gene Model | MGI Sequence Detail 17022 C57BL/6J ±  kb
    transcript NM_025902 RefSeq | MGI Sequence Detail 2885 C57BL/6  
    polypeptide Q9CQB5 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005502 CDGSH iron-sulfur domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR045131 CDGSH iron-sulfur domain-containing protein 1/2
      IPR018967 Iron-binding zinc finger, CDGSH type
      IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
      IPR042216 MitoNEET, CDGSH iron-sulfur domain
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 94

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916247, MGI:1916261, MGI:2139813, MGI:2442890
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 7
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:334600 Yeh CH, et al., Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. J Biomed Sci. 2022 Jul 24;29(1):53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory