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Mdk Gene Detail
Summary
  • Symbol
    Mdk
  • Name
    midkine
  • Synonyms
    Mek, MK
  • Feature Type
    protein coding gene
  • IDs
    MGI:96949
    NCBI Gene: 17242
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91760149-91762348 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96949
 protein coding gene Chr2:91760149-91762642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026159
 protein coding gene Chr2:93313688-93316154 (-)
A/J MGP_AJ_G0026120
 protein coding gene Chr2:89554946-89557484 (-)
AKR/J MGP_AKRJ_G0026101
 protein coding gene Chr2:92027606-92031150 (-)
BALB/cJ MGP_BALBcJ_G0026129
 protein coding gene Chr2:89741055-89743533 (-)
C3H/HeJ MGP_C3HHeJ_G0025880
 protein coding gene Chr2:92327731-92329706 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026580
 protein coding gene Chr2:96541982-96544487 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023971
 protein coding gene Chr2:86048907-86051395 (-)
CAST/EiJ MGP_CASTEiJ_G0025345
 protein coding gene Chr2:92868868-92871371 (-)
CBA/J MGP_CBAJ_G0025858
 protein coding gene Chr2:99881473-99883979 (-)
DBA/2J MGP_DBA2J_G0025994
 protein coding gene Chr2:89151709-89154191 (-)
FVB/NJ MGP_FVBNJ_G0025957
 protein coding gene Chr2:88248683-88251855 (-)
LP/J MGP_LPJ_G0026098
 protein coding gene Chr2:93509963-93513721 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025983
 protein coding gene Chr2:102878740-102881222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026634
 protein coding gene Chr2:92114443-92116935 (-)
PWK/PhJ MGP_PWKPhJ_G0025080
 protein coding gene Chr2:88888313-88890774 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024881
 protein coding gene Chr2:91675348-91677758 (-)
WSB/EiJ MGP_WSBEiJ_G0025412
 protein coding gene Chr2:92717761-92720304 (-)



Homology
more
  • Human Ortholog
    MDK, midkine
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDK, midkine
  • Synonyms
    ARAP, MK, NEGF2
  • Links
    NCBI Gene ID: 4192
    neXtProt AC: NX_P21741
    UniProt: P21741

  • Chr Location
    11p11.2; chr11:46380756-46383837 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mdk mouse models; 1 with human MDK associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially normal except for some delayed development of the hippocampus and behavioral abnormalities when young.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1400
  • Tissues
    445
  • cDNA Data
    190
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17242 NCBI Gene Model | MGI Sequence Detail 2200 C57BL/6J ±  kb
    transcript NM_001012335 RefSeq | MGI Sequence Detail 922 ZRU/MplStud  
    polypeptide P12025 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010265 midkine
      (term hierarchy)
    • InterPro Domains
      IPR000762 Midkine heparin-binding growth factor
      IPR020090 Pleiotrophin/Midkine, C-terminal domain
      IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamily
      IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
      IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved site
      IPR020089 Pleiotrophin/Midkine, N-terminal domain
      IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 4
      cDNA 190
      Primer pair 10
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12166, MGD-MRK-12189
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 24
      Phenotypes 62
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory