Sequence Detail

ID/Version

P12025 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Midkine {ECO:0000303|PubMed:8827451}; Short=MK {ECO:0000303|PubMed:2345177};AltName: Full=Retanoic acid-responsive protein {ECO:0000303|PubMed:2355021};AltName: Full=Retinoic acid-induced differentiation factor;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 140 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mdk	midkine	92	133	4	71

Sequence references in MGI

J:9111 Kadomatsu K, et al., cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun. 1988 Mar 30;151(3):1312-8
J:10523 Matsubara S, et al., Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis. J Biol Chem. 1990 Jun 5;265(16):9441-3
J:34016 Kaneda N, et al., Midkine, a heparin-binding growth/differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro. J Biochem. 1996 Jun;119(6):1150-6
J:35030 Tomomura M, et al., A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. J Biol Chem. 1990 Jun 25;265(18):10765-70
J:60666 Horiba M, et al., Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Invest. 2000 Feb;105(4):489-95
J:76278 Nakamura E, et al., Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells. 1998 Dec;3(12):811-22
J:93637 Kawai H, et al., Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Am J Pathol. 2004 Nov;165(5):1603-12
J:102069 Ochiai K, et al., The role of midkine and pleiotrophin in liver regeneration. Liver Int. 2004 Oct;24(5):484-91
J:110520 Zou P, et al., Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of beta-tectorin gene and in auditory response. Lab Invest. 2006 Jul;86(7):645-53
J:117275 Ichihara-Tanaka K, et al., Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. J Biol Chem. 2006 Oct 13;281(41):30857-64
J:123392 Muramatsu H, et al., Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors. Genes Cells. 2006 Dec;11(12):1405-17
J:126406 Horiba M, et al., Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction. Circulation. 2006 Oct 17;114(16):1713-20
J:146315 Takenaka H, et al., Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H462-9
J:147025 Zou P, et al., Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth. J Neurochem. 2006 Dec;99(6):1470-9
J:172537 Liedert A, et al., Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. Bone. 2011 Apr 1;48(4):945-51
J:181857 Sonobe Y, et al., Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. J Immunol. 2012 Mar 15;188(6):2602-11
J:209651 Weckbach LT, et al., The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18). Blood. 2014 Mar 20;123(12):1887-96
J:225370 Haffner-Luntzer M, et al., Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. PLoS One. 2014;9(12):e116282
J:233132 Neunaber C, et al., Increased trabecular bone formation in mice lacking the growth factor midkine. J Bone Miner Res. 2010 Aug;25(8):1724-35
J:241140 Masuda T, et al., Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis. Am J Pathol. 2017 Apr;187(4):740-751
J:269128 Lautz T, et al., Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3. EBioMedicine. 2018 Jan;27:237-246
J:273528 Ueoka C, et al., Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate. J Biol Chem. 2000 Dec 1;275(48):37407-13
J:273581 Nakanishi T, et al., Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. J Biochem. 1997 Feb;121(2):197-205
J:273653 Kurosawa N, et al., Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Glycoconj J. 2001 Jun;18(6):499-507