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Rab23 Gene Detail
Summary
  • Symbol
    Rab23
  • Name
    RAB23, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:99833
    NCBI Gene: 19335
  • Gene Overview
    MyGene.info: RAB23
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:33719887-33742564 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22678 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 12.80 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC137
  • Links
    NCBI Gene ID: 51715
    neXtProt AC: NX_Q9ULC3
    UniProt: Q9ULC3

  • Chr Location
    6p12.1-p11.2; chr6:57186992-57222314 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RAB23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele show neural tube defects, exencephaly, spinal cord and dorsal root ganglia anomalies, malformed eyes and defects in the axial skeleton and developing limbs. Mice homozygous for an ENU-induced allele die in utero with exencephaly, polydactyly and eye defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021871 VEGA Gene Model | MGI Sequence Detail 22678 C57BL/6J ±  kb
    transcript OTTMUST00000051907 VEGA | MGI Sequence Detail 4322 Not Applicable  
    polypeptide OTTMUSP00000024509 VEGA | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      149 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR034114 Ras-related protein Rab-23
      IPR001806 Small GTPase superfamily
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
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    • All nucleic 71
      Genomic 1
      cDNA 67
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
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    MGD-MRK-16622, MGD-MRK-31043, MGI:104970, MGI:1276114, MGI:2138599
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
    • Latest
      J:243907 Snouffer A, et al., Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory