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Rab23
Gene Detail
 Symbol
Name
ID
Rab23
RAB23, member RAS oncogene family
MGI:99833
Feature Type protein coding gene
Genetic Map
Chromosome 1
12.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:33719887-33742564 bp, + strand
From VEGA annotation of GRCm38

  22678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab23

Human
homologs
Human Homolog RAB23, RAB23, member RAS oncogene family
NCBI Gene ID 51715
neXtProt AC  NX_Q9ULC3
Human Synonyms  HSPC137
Human Chr (Location)  6p11; chr6:57186992-57222314 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAB23
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(17) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele show neural tube defects, exencephaly, spinal cord and dorsal root ganglia anomalies, malformed eyes and defects in the axial skeleton and developing limbs. Mice homozygous for an ENU-induced allele die in utero with exencephaly, polydactyly and eye defects.
 
Phenotype Images(1)
Interactions
Rab23 interacts with 287 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process autophagic vacuole assembly, cellular defense response, ...
Component autophagic vacuole, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (98)    Tissues (63)    Images (27)
Theiler Stages: 1, 2, 3, 4, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 91
RT-PCR 7
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(1) cDNA(67) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021871 (Evidence)
Ensembl Gene ModelENSMUSG00000004768 (Evidence)
Entrez Gene19335 (Evidence)
UniGene86744
DFCITC1579183, TC1611497, TC1654011
DoTSDT.101380917, DT.110925019, DT.91446707, DT.94131461, DT.97389949
NIA Mouse Gene IndexU042150
PDB1Z2A, 1Z22
Consensus CDS ProjectCCDS35532.1
International Mouse Knockout Project StatusRab23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021871 VEGA Gene Model | MGI Sequence Detail 22678 C57BL/6J ±  kb
transcript OTTMUST00000051907 VEGA | MGI Sequence Detail 4330 Not Applicable 
polypeptide OTTMUSP00000024509 VEGA | MGI Sequence Detail 237 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013596 ras-related protein Rab-23
References (Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:186861 Sun M, et al., Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012 Jan;2(1):143-50
All references(57)
Other
accession IDs
MGD-MRK-16622, MGD-MRK-31043, MGI:104970, MGI:1276114, MGI:2138599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory