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Rab23 Gene Detail
Summary
  • Symbol
    Rab23
  • Name
    RAB23, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:99833
    NCBI Gene: 19335
  • Gene Overview
    MyGene.info: RAB23
Location & Maps
more
  • Sequence Map
    Chr1:33719887-33742564 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22678 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 12.80 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC137
  • Links
    NCBI Gene ID: 51715
    neXtProt AC: NX_Q9ULC3

  • Chr Location
    6p12.1-p11.2; chr6:57186992-57222314 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RAB23 associations

Human Disease Mouse Models
       Carpenter Syndrome 1; CRPT1   OMIM: 201000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 5 genetic backgrounds
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Rab23
  • Incidental Mutations
Mice homozygous for a spontaneous allele show neural tube defects, exencephaly, spinal cord and dorsal root ganglia anomalies, malformed eyes and defects in the axial skeleton and developing limbs. Mice homozygous for an ENU-induced allele die in utero with exencephaly, polydactyly and eye defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021871 VEGA Gene Model | MGI Sequence Detail 22678 C57BL/6J ±  kb
transcript OTTMUST00000051907 VEGA | MGI Sequence Detail 4322 Not Applicable  
polypeptide OTTMUSP00000024509 VEGA | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 71
    Genomic 1
    cDNA 67
    Primer pair 1
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-16622, MGD-MRK-31043, MGI:104970, MGI:1276114, MGI:2138599
References
more
  • Summaries
    All 58
    Developmental Gene Expression 9
    Gene Ontology 12
    Phenotypes 28
  • Earliest
    J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
  • Latest
    J:214665 Fuller K, et al., Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014 Jul 15;391(2):182-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory