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Rab23 Gene Detail
Summary
  • Symbol
    Rab23
  • Name
    RAB23, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:99833
    NCBI Gene: 19335
  • Gene Overview
    MyGene.info: RAB23
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:33719888-33742564 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 12.80 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99833
protein coding gene Chr1:33719887-33742564 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015902
protein coding gene Chr1:32083383-32109724 (+)
A/J MGP_AJ_G0015886
protein coding gene Chr1:31318016-31340571 (+)
AKR/J MGP_AKRJ_G0015842
protein coding gene Chr1:31682905-31705530 (+)
BALB/cJ MGP_BALBcJ_G0015840
protein coding gene Chr1:30961157-30985506 (+)
C3H/HeJ MGP_C3HHeJ_G0015674
protein coding gene Chr1:31877492-31901581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016293
protein coding gene Chr1:33565507-33589346 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014015
protein coding gene Chr1:28492490-28515534 (+)
CAST/EiJ MGP_CASTEiJ_G0015254
protein coding gene Chr1:31724640-31748042 (+)
CBA/J MGP_CBAJ_G0015645
protein coding gene Chr1:34469754-34497360 (+)
DBA/2J MGP_DBA2J_G0015746
protein coding gene Chr1:30646071-30669102 (+)
FVB/NJ MGP_FVBNJ_G0015748
protein coding gene Chr1:30195068-30218310 (+)
LP/J MGP_LPJ_G0015816
protein coding gene Chr1:32425863-32451505 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015768
protein coding gene Chr1:36756223-36783192 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016340
protein coding gene Chr1:31655964-31681702 (+)
PWK/PhJ MGP_PWKPhJ_G0015037
protein coding gene Chr1:30373567-30396759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014820
protein coding gene Chr1:31653356-31675713 (+)
WSB/EiJ MGP_WSBEiJ_G0015316
protein coding gene Chr1:31646484-31672140 (+)



Homology
more
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB23, RAB23, member RAS oncogene family
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC137
  • Links
    NCBI Gene ID: 51715
    neXtProt AC: NX_Q9ULC3
    UniProt: Q9ULC3

  • Chr Location
    6p12.1-p11.2; chr6:57186992-57222314 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RAB23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele show neural tube defects, exencephaly, spinal cord and dorsal root ganglia anomalies, malformed eyes and defects in the axial skeleton and developing limbs. Mice homozygous for an ENU-induced allele die in utero with exencephaly, polydactyly and eye defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19335 NCBI Gene Model | MGI Sequence Detail 22677 C57BL/6J ±  kb
    transcript NM_008999 RefSeq | MGI Sequence Detail 4321 C57BL/6  
    polypeptide P35288 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 1
      cDNA 68
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16622, MGD-MRK-31043, MGI:104970, MGI:1276114, MGI:2138599
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
    • Latest
      J:243907 Snouffer A, et al., Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory