Rab23
Gene Detail

Symbol Name ID

Rab23 RAB23, member RAS oncogene family MGI:99833

Feature Type

protein coding gene

Genetic Map

Chromosome 1

12.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:33719882-33742564 bp, + strand From VEGA annotation of GRCm38   22683 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab23

Human homologs

Human Homolog		RAB23, RAB23, member RAS oncogene family
NCBI Gene ID		51715
neXtProt AC		NX_Q9ULC3
Human Synonyms		HSPC137
Human Chr (Location)		6p11; chr6:57053581-57087078 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAB23

Alleles and phenotypes

All alleles(21) : Targeted(2) Gene trapped(17) Spontaneous(1) Chemically induced(1)
 

Mice homozygous for a spontaneous allele show neural tube defects, exencephaly, spinal cord and dorsal root ganglia anomalies, malformed eyes and defects in the axial skeleton and developing limbs. Mice homozygous for an ENU-induced allele die in utero with exencephaly, polydactyly and eye defects.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	autophagic vacuole assembly, cellular defense response, ...
Component	autophagic vacuole, cytoplasm, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (100)    Tissues (65)    Images (27)
Theiler Stages: 1, 2, 3, 5, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	91
RT-PCR	9

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(71) Genomic(1) cDNA(68) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021871 (Evidence)
Ensembl Gene Model	ENSMUSG00000004768 (Evidence)
Entrez Gene	19335 (Evidence)
UniGene	86744
DFCI	TC1579183, TC1611497, TC1654011
DoTS	DT.101380917, DT.110925019, DT.91446707, DT.94131461, DT.97389949
NIA Mouse Gene Index	U042150
PDB	1Z2A, 1Z22
Consensus CDS Project	CCDS35532.1
International Mouse Knockout Project Status	Rab23

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021871	VEGA Gene Model | MGI Sequence Detail	22683	C57BL/6J
transcript	OTTMUST00000051907	VEGA | MGI Sequence Detail	4335	Not Applicable
polypeptide	OTTMUSP00000024509	VEGA | MGI Sequence Detail	237	Not Applicable

All sequences(58) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(94 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013596	ras-related protein Rab-23

References

(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:186861 Sun M, et al., Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012 Jan;2(1):143-50
All references(56)

Other accession IDs

MGD-MRK-16622, MGD-MRK-31043, MGI:104970, MGI:1276114, MGI:2138599