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Prdm1
Gene Detail
Symbol

Name
ID
Prdm1
PR domain containing 1, with ZNF domain
MGI:99655
Synonyms
b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
23.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:44437177-44528501 bp, - strand
From VEGA annotation of GRCm38

  91325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDM1
Protein SuperFamily: PR-domain zinc finger protein PRDM1
Gene Tree: Prdm1

Human
homologs
PRDM1, PR domain containing 1, with ZNF domain
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 639
neXtProt AC: NX_O75626

Human Synonyms: BLIMP1, PRDI-BF1

Human Chr (Location): 6q21; chr6:106086320-106109939 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(16)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality and impaired primordial germ cell development, while heterozygotes display a decreased numbers of primordial germ cells but normal migration. Conditional mutants display impaired plasma cell and pre-plasma memory B cell development.
 
Human Diseases Modeled in Mice Using Prdm1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(13)
Interactions
Prdm1 interacts with 374 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (47 records)
Data Summary: Results (259)    Tissues (169)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 63
RNA in situ 152
RT-PCR 44
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prdm1 ; ZFIN prdm1a, prdm1b    NEW 
Molecular
reagents
All nucleic(40) cDNA(37) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035215 (Evidence)
Ensembl Gene Model ENSMUSG00000038151 (Evidence)
Entrez Gene 12142 (Evidence)
UniGene 4800
DFCI TC1584436, TC1627325
DoTS DT.101725432, DT.40145588, DT.55175601
NIA Mouse Gene Index U031748
EC 2.1.1.-
Consensus CDS Project CCDS23825.2
International Mouse Phenotyping Consortium Status Prdm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035215 VEGA Gene Model | MGI Sequence Detail 91325 C57BL/6J ±  kb
transcript OTTMUST00000089714 VEGA | MGI Sequence Detail 5281 Not Applicable 
polypeptide OTTMUSP00000049054 VEGA | MGI Sequence Detail 856 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016608 PR-domain zinc finger protein PRDM1
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001831 PR domain zinc finger protein 1
References
(Earliest) J:17825 Turner CA Jr, et al., Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell. 1994 Apr 22;77(2):297-306
(Latest) J:221793 Okamura T, et al., TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329
All references(176)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16440, MGI:5446148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory