About   Help   FAQ
Prdm1
Gene Detail
Symbol

Name
ID
Prdm1
PR domain containing 1, with ZNF domain
MGI:99655
Synonyms
b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
23.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:44437177-44528501 bp, - strand
From VEGA annotation of GRCm38

  91325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: PR-domain zinc finger protein PRDM1
Gene Tree: Prdm1

Human
homologs
Human Homolog PRDM1, PR domain containing 1, with ZNF domain
NCBI Gene ID 639
neXtProt AC  NX_O75626
Human Synonyms  BLIMP1, PRDI-BF1
Human Chr (Location)  6q21; chr6:106086320-106109939 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality and impaired primordial germ cell development, while heterozygotes display a decreased numbers of primordial germ cells but normal migration. Conditional mutants display impaired plasma cell and pre-plasma memory B cell development.
 
Human Diseases Modeled Using Mouse Prdm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(13)
Interactions
Prdm1 interacts with 374 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (40 records)
Data Summary: Results (259)    Tissues (169)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 63
RNA in situ 152
RT-PCR 44
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(37) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035215 (Evidence)
Ensembl Gene ModelENSMUSG00000038151 (Evidence)
Entrez Gene12142 (Evidence)
UniGene4800
DFCITC1584436, TC1627325
DoTSDT.101725432, DT.40145588, DT.55175601
NIA Mouse Gene IndexU031748
EC2.1.1.-
Consensus CDS ProjectCCDS23825.2
International Mouse Knockout Project StatusPrdm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035215 VEGA Gene Model | MGI Sequence Detail 91325 C57BL/6J ±  kb
transcript OTTMUST00000089714 VEGA | MGI Sequence Detail 5281 Not Applicable 
polypeptide OTTMUSP00000049054 VEGA | MGI Sequence Detail 856 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016608 PR-domain zinc finger protein PRDM1
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001831 PR domain zinc finger protein 1
References
(Earliest) J:17825 Turner CA Jr, et al., Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell. 1994 Apr 22;77(2):297-306
(Latest) J:213584 Vincent SD, et al., Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014 Oct 1;23(19):5087-101
All references(166)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16440, MGI:5446148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory