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Phenotypes Associated with This Genotype
Genotype
MGI:5515634
Allelic
Composition
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Clme mutation (1 available); any Prdm1 mutation (64 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells
• more spontaneous germinal center B cells
• increase in the percentage and number of follicular T helper cells
• more germinal centers in the spleen
• total number of splenocytes are increased in females but not males
• enhanced immune response after NP-CGG immunization with an increased high-affinity anti-NP IgG response, an increase in the number of germinal center B cells, and an increase in the number of total germinal cells and antigen-specific germinal cells
• enhanced germinal center response in young mice
• total serum immunoglobulin levels are increased in females but not males
• kidney deposition of IgG in 10 month old females
• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls
• increase in production of IL-6 by splenic dendritic cells and by bone marrow derived dendritic cells after LPS stimulation in females but not males
• females, but not males, develop autoantibodies as early as 4-5 months of age, including anti-nuclear antibodies, anti-double stranded dNA, and anti-ENA5, which are all IgG
• IgG2b is the major isotype of anti-dsDNA antibodies
• inflammatory infiltrates in 10 month old females

renal/urinary system
• proteinuria in 10 month old females
• inflammatory infiltrates in 10 month old females
• kidney deposition of IgG in 10 month old females
• mesangial cell proliferation in 10 month old females

hematopoietic system
• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells
• more spontaneous germinal center B cells
• increase in the percentage and number of follicular T helper cells
• more germinal centers in the spleen
• total number of splenocytes are increased in females but not males
• enhanced germinal center response in young mice
• total serum immunoglobulin levels are increased in females but not males
• kidney deposition of IgG in 10 month old females
• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

homeostasis/metabolism
• proteinuria in 10 month old females

cellular
• mesangial cell proliferation in 10 month old females


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory