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Zap70
Gene Detail
 Symbol
Name
ID
Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613
Synonyms Srk, TZK, ZAP-70
Feature Type protein coding gene
Genetic Map
Chromosome 1
15.41 cM, cytoband A4-C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:36761798-36782816 bp, + strand
From VEGA annotation of GRCm38

  21019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree: Zap70

Human
homologs
Human Homolog ZAP70, zeta-chain (TCR) associated protein kinase 70kDa
NCBI Gene ID 7535
neXtProt AC  NX_P43403
Human Synonyms  SRK, STCD, STD, TZK, ZAP-70
Human Chr (Location)  2q12; chr2:97713568-97739860 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZAP70
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(6) Gene trapped(1) Spontaneous(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.
 
Human Diseases Modeled Using Mouse Zap70 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zap70 interacts with 17 markers (Mir16-2, Mir23a, Mir135a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process beta selection, immune response, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (33)    Tissues (26)   
Theiler Stages: 23, 26, 27, 28
Assay TypeResults
RNA in situ 19
Northern blot 14
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000049481 (Evidence)
Ensembl Gene ModelENSMUSG00000026117 (Evidence)
Entrez Gene22637 (Evidence)
UniGene8038
DFCITC1595051, TC1598098, TC1656810, TC1657079, TC1675293
DoTSDT.101165371, DT.101379563, DT.486343, DT.99688718, DT.99838835
NIA Mouse Gene IndexU000165
EC2.7.10.2
Consensus CDS ProjectCCDS14888.1
International Mouse Knockout Project StatusZap70
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049481 VEGA Gene Model | MGI Sequence Detail 21019 C57BL/6J ±  kb
transcript OTTMUST00000126145 VEGA | MGI Sequence Detail 2243 Not Applicable 
polypeptide OTTMUSP00000068269 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
InterPro IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Protein Ontology PR:000003064 tyrosine-protein kinase ZAP-70
References (Earliest) J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
(Latest) J:211840 Siggs OM, et al., A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. Immunology. 2014 Apr;141(4):587-95
All references(110)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory