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Gene Detail
zeta-chain (TCR) associated protein kinase
Synonyms Srk, TZK, ZAP-70
Feature Type protein coding gene
Genetic Map
Chromosome 1
15.41 cM, cytoband A4-C1
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr1:36761861-36782816 bp, + strand
From NCBI annotation of GRCm38

  20956 bp   ±  kb flank

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Mouse Genome Browser
HomoloGene:839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree: Zap70

Human Homolog ZAP70, zeta-chain (TCR) associated protein kinase 70kDa
NCBI Gene ID 7535
neXtProt AC  NX_P43403
Human Synonyms  SRK, STCD, STD, TZK, ZAP-70
Human Chr (Location)  2q12; chr2:97713568-97739860 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZAP70
All alleles(17) : Chemically induced (ENU)(5) Gene trapped(1) Spontaneous(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.
Human Diseases Modeled Using Mouse Zap70 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
All GO classifications: (50 annotations)
Process beta selection, immune response, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Literature Summary: (1 records)
Data Summary: Results (33)    Tissues (21)   
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 19
Northern blot 14
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(6)
Other database
Ensembl Gene ModelENSMUSG00000026117 (Evidence)
Entrez Gene22637 (Evidence)
DFCITC1595051, TC1598098, TC1656810, TC1657079, TC1675293
DoTSDT.101165371, DT.101379563, DT.486343, DT.99688718, DT.99838835
NIA Mouse Gene IndexU000165
Consensus CDS ProjectCCDS14888.1
International Mouse Knockout Project StatusZap70
Representative SequencesLengthStrain/SpeciesFlank
genomic 22637 NCBI Gene Model | MGI Sequence Detail 20956 C57BL/6J ±  kb
transcript NM_001289765 RefSeq | MGI Sequence Detail 2290 C57BL/6 
polypeptide P43404 UniProt | EBI | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(10) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
InterPro IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Protein Ontology PR:000003064 tyrosine-protein kinase ZAP-70
Graphical View of Protein Domain Structure
References (Earliest) J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
(Latest) J:208981 Wencker M, et al., Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol. 2014 Jan;15(1):80-7
All references(107)
accession IDs
MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.18
The Jackson Laboratory