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Zap70 Gene Detail
Summary
  • Symbol
    Zap70
  • Name
    zeta-chain (TCR) associated protein kinase
  • Synonyms
    Srk, TZK, ZAP-70
  • Feature Type
    protein coding gene
  • IDs
    MGI:99613
    NCBI Gene: 22637
  • Gene Overview
    MyGene.info: ZAP70
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36761798-36782818 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.41 cM, cytoband A4-C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99613
protein coding gene Chr1:36761798-36782821 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015932
protein coding gene Chr1:35322765-35345120 (+)
A/J MGP_AJ_G0015916
protein coding gene Chr1:34374511-34393215 (+)
AKR/J MGP_AKRJ_G0015871
protein coding gene Chr1:34853921-34873471 (+)
BALB/cJ MGP_BALBcJ_G0015870
protein coding gene Chr1:34053791-34072211 (+)
C3H/HeJ MGP_C3HHeJ_G0015703
protein coding gene Chr1:35053402-35080277 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016323
protein coding gene Chr1:36909783-36936765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014045
protein coding gene Chr1:31412797-31433758 (+)
CAST/EiJ MGP_CASTEiJ_G0015284
protein coding gene Chr1:34942303-34964982 (+)
CBA/J MGP_CBAJ_G0015675
protein coding gene Chr1:37892737-37920591 (+)
DBA/2J MGP_DBA2J_G0015776
protein coding gene Chr1:33702663-33724091 (+)
FVB/NJ MGP_FVBNJ_G0015778
protein coding gene Chr1:33226490-33248254 (+)
LP/J MGP_LPJ_G0015846
protein coding gene Chr1:35693938-35713942 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015798
protein coding gene Chr1:40083949-40110796 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016370
protein coding gene Chr1:34901178-34922247 (+)
PWK/PhJ MGP_PWKPhJ_G0015067
protein coding gene Chr1:33459462-33482213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014849
protein coding gene Chr1:34842363-34867246 (+)
WSB/EiJ MGP_WSBEiJ_G0015346
protein coding gene Chr1:34849588-34874119 (+)



Homology
more
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70
  • Links
    NCBI Gene ID: 7535
    neXtProt AC: NX_P43403
    UniProt: P43403

  • Chr Location
    2q11.2; chr2:97712030-97744327 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Zap70 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 18 alleles in 22 genetic backgrounds
    50 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026117 Ensembl Gene Model | MGI Sequence Detail 21021 C57BL/6J ±  kb
    transcript ENSMUST00000027291 Ensembl | MGI Sequence Detail 2245 Not Applicable  
    polypeptide ENSMUSP00000027291 Ensembl | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 25

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 24
      Phenotypes 76
    • Earliest
      J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
    • Latest
      J:265220 Napier RJ, et al., Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis. J Immunol. 2018 Oct 1;201(7):1889-1898

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory