About   Help   FAQ
Zap70 Gene Detail
Summary
  • Symbol
    Zap70
  • Name
    zeta-chain (TCR) associated protein kinase
  • Synonyms
    Srk, TZK, ZAP-70
  • Feature Type
    protein coding gene
  • IDs
    MGI:99613
    NCBI Gene: 22637
  • Gene Overview
    MyGene.info: ZAP70
Location & Maps
more
  • Sequence Map
    Chr1:36761798-36782818 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21021 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.41 cM, cytoband A4-C1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70kDa
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70kDa
    Orthology source: HomoloGene
  • Synonyms
    SRK, STCD, STD, TZK, ZAP-70
  • Links
    NCBI Gene ID: 7535
    neXtProt AC: NX_P43403

  • Chr Location
    2q12; chr2:97713568-97744327 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Zap70 mouse models; 1 with human ZAP70 associations

Human Disease Mouse Models
       Rheumatoid Arthritis; RA   OMIM: 180300 View 1 model
       Selective T-Cell Defect; STCD   OMIM: 269840
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 14 alleles in 18 genetic backgrounds
    50 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (ENU)
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Spontaneous
    2
  • Targeted
    11
  • Transgenic
    5
  • Genomic Mutations
    1 involving Zap70
  • Incidental Mutations
Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049481 VEGA Gene Model | MGI Sequence Detail 21021 C57BL/6J ±  kb
transcript OTTMUST00000126145 VEGA | MGI Sequence Detail 2245 Not Applicable  
polypeptide OTTMUSP00000068269 VEGA | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    78 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003064 tyrosine-protein kinase ZAP-70
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR000980 SH2 domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
    IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 24

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398
References
more
  • Summaries
    All 115
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 20
    Phenotypes 63
  • Earliest
    J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
  • Latest
    J:230916 Chiang YJ, et al., Regulation of T cell development by c-Cbl: essential role of Lck. Int Immunol. 2015 May;27(5):245-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory