Zap70
Gene Detail

Symbol Name ID

Zap70 zeta-chain (TCR) associated protein kinase MGI:99613

Synonyms

Srk, TZK, ZAP-70

Feature Type

protein coding gene

Genetic Map

Chromosome 1

15.41 cM, cytoband A4-C1
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:36761861-36782816 bp, + strand From NCBI annotation of GRCm38   20956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree: Zap70

Human homologs

Human Homolog		ZAP70, zeta-chain (TCR) associated protein kinase 70kDa
NCBI Gene ID		7535
neXtProt AC		NX_P43403
Human Synonyms		SRK, STCD, STD, TZK, ZAP-70
Human Chr (Location)		2q12; chr2:98330031-98356323 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ZAP70

Alleles and phenotypes

All alleles(17) : Targeted(9) Gene trapped(1) Spontaneous(2) Chemically induced(5)
 

Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.

 
Human Diseases Modeled Using Mouse Zap70 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	beta selection, immune response, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (33)    Tissues (21)   
Theiler Stages: 23, 26, 28

Assay Type	Results
RNA in situ	19
Northern blot	14

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(22)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000026117 (Evidence)
Entrez Gene	22637 (Evidence)
UniGene	8038
DFCI	TC1595051, TC1598098, TC1656810, TC1675293
DoTS	DT.101379563, DT.486343, DT.99688718, DT.99838835
NIA Mouse Gene Index	U000165
EC	2.7.10.2
Consensus CDS Project	CCDS14888.1
International Mouse Knockout Project Status	Zap70

Sequences

Length	Strain/Species
genomic	22637	NCBI Gene Model | MGI Sequence Detail	20956	C57BL/6J
transcript	NM_009539	RefSeq | MGI Sequence Detail	2180	C57BL/6
polypeptide	P43404	UniProt | EBI | MGI Sequence Detail	618	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70
InterPro	IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Protein Ontology	PR:000003064	tyrosine-protein kinase ZAP-70

Graphical View of Protein Domain Structure

References

(Earliest) J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
(Latest) J:189787 Lesourne R, et al., Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012 Aug 1;189(3):1154-61
All references(102)

Other accession IDs

MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398