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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613
19 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Foxp3tm2Ayr/?
\Zap70rps/\Zap70rps
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:211510
abnormal double-positive T cell morphology J:211510
abnormal regulatory T cell number J:211510
abnormal T cell differentiation J:211510
decreased CD4-positive, alpha-beta T cell number J:211510
decreased CD8-positive, alpha-beta T cell number J:211510
normal immune system phenotype J:211510
\Slatm1Weis/\Slatm1Weis
\Zap70tm1Weis/\Zap70tm1Weis
involves: 129 * 129X1/SvJ * C57BL/6 		abnormal T cell differentiation J:71804
decreased CD4-positive, alpha-beta T cell number J:71804
\Syktm1Kuro/\Syktm1Kuro
\Zap70tm1Dlo/\Zap70tm1Dlo
\Cd79atm1(cre)Reth/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal pro-B cell differentiation J:134528
\Zap70m1Saka/\Zap70m1Saka
\Tg(DO11.10)10Dlo/0
involves: BALB/c * C3H * C57BL/6 		decreased T cell number J:86607
decreased T cell proliferation J:86607
\Zap70m1Saka/\Zap70m1Saka
\Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: BALB/c * C57BL/6J * DBA/2J 		abnormal positive T cell selection J:86607
autoimmune arthritis J:86607
\Zap70m1Saka/\Zap70tm1Dlo
\Tg(Lck-ZAP70)824Saka/0
involves: 129P2/OlaHsd * BALB/c 		no abnormal phenotype detected J:86607
\Zap70tm1.1Mmal/\Zap70tm1.1Mmal
\Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J 		normal immune system phenotype J:71099
\Zap70tm1.1Mmal/\Zap70tm1.1Mmal
\Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2 		abnormal cytokine secretion J:71099
abnormal T cell proliferation J:71099
normal immune system phenotype J:71099
\Zap70tm2.1Mmal/\Zap70tm2.1Mmal
\Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J 		abnormal lymph node cell ratio J:71099
abnormal T cell morphology J:71099
abnormal thymus cell ratio J:71099
normal immune system phenotype J:71099
\Zap70tm2.1Mmal/\Zap70tm2.1Mmal
\Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2 		abnormal T cell morphology J:71099
normal immune system phenotype J:71099
\Zap70tm2.1Weis/\Zap70tm2.1Weis
\Tg(DO11.10)10Dlo/?
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6 		abnormal positive T cell selection J:154166
\Zap70tm2.1Weis/\Zap70tm2.1Weis
\Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S4/SvJae * C57BL/6J * DBA/2J 		abnormal positive T cell selection J:154166
abnormal T cell clonal deletion J:154166
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory