Zap70 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Foxp3^tm2Ayr/? Zap70^rps/Zap70^rps involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal CD4-positive, alpha beta T cell morphology	J:211510
	abnormal double-positive T cell morphology	J:211510
	abnormal regulatory T cell number	J:211510
	abnormal T cell differentiation	J:211510
	decreased CD4-positive, alpha-beta T cell number	J:211510
	decreased CD8-positive, alpha-beta T cell number	J:211510
	normal immune system phenotype	J:211510
Sla^tm1Weis/Sla^tm1Weis Zap70^tm1Weis/Zap70^tm1Weis involves: 129 * 129X1/SvJ * C57BL/6	abnormal T cell differentiation	J:71804
	decreased CD4-positive, alpha-beta T cell number	J:71804
Syk^tm1Kuro/Syk^tm1Kuro Zap70^tm1Dlo/Zap70^tm1Dlo Cd79a^tm1(cre)Reth/? involves: 129P2/OlaHsd * BALB/c * C57BL/6	abnormal pro-B cell differentiation	J:134528
Zap70^m1Saka/Zap70^m1Saka Tg(DO11.10)10Dlo/0 involves: BALB/c * C3H * C57BL/6	decreased T cell number	J:86607
	decreased T cell proliferation	J:86607
Zap70^m1Saka/Zap70^m1Saka Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: BALB/c * C57BL/6J * DBA/2J	abnormal positive T cell selection	J:86607
	arthritis	J:86607
Zap70^m1Saka/Zap70^tm1Dlo Tg(Lck-ZAP70)824Saka/0 involves: 129P2/OlaHsd * BALB/c	no abnormal phenotype detected	J:86607
Zap70^tm1.1Mmal/Zap70^tm1.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J	normal immune system phenotype	J:71099
Zap70^tm1.1Mmal/Zap70^tm1.1Mmal Tg(TcrLCMV)327Sdz/0 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2	abnormal cytokine secretion	J:71099
	abnormal T cell proliferation	J:71099
	normal immune system phenotype	J:71099
Zap70^tm2.1Mmal/Zap70^tm2.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J	abnormal lymph node cell ratio	J:71099
	abnormal T cell morphology	J:71099
	abnormal thymus cell ratio	J:71099
	normal immune system phenotype	J:71099
Zap70^tm2.1Mmal/Zap70^tm2.1Mmal Tg(TcrLCMV)327Sdz/0 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2	abnormal T cell morphology	J:71099
	normal immune system phenotype	J:71099
Zap70^tm2.1Weis/Zap70^tm2.1Weis Tg(DO11.10)10Dlo/? involves: 129S4/SvJae * BALB/c * C3H * C57BL/6	abnormal positive T cell selection	J:154166
Zap70^tm2.1Weis/Zap70^tm2.1Weis Tg(TcraH-Y,TcrbH-Y)71Vbo/? involves: 129S4/SvJae * C57BL/6J * DBA/2J	abnormal positive T cell selection	J:154166
	abnormal T cell clonal deletion	J:154166

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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