Tg(Lck-ZAP70)824Saka
Transgene Detail

Summary

• Symbol: Tg(Lck-ZAP70)824Saka
• Name: transgene insertion 824, Shimon Sakaguchi
• MGI ID: MGI:3698650
• Transgene: Tg(Lck-ZAP70)824Saka Location: unknown
• Alliance: Tg(Lck-ZAP70)824Saka page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-ZAP70)824Saka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ZAP70 (7535)

  Zap70

  (MGI:99613)

• Mutation details: Expression of human ZAP70 is controlled by the Lck proximal promoter. Thymocytes and peripheral T cells express the transgene. (J:86607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86607 Sakaguchi N, et al., Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60
• All: 1 reference(s)