Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; T cell selection; and positive regulation of alpha-beta T cell activation. Located in cell-cell junction; cytosol; and immunological synapse. Is expressed in brain; gut; hemolymphoid system gland; liver; and lung epithelium. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).