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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613
62 phenotypes from 19 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Zap70m1Btlr/\Zap70m1Btlr
involves: C57BL/6J 		abnormal class switch recombination J:185495
abnormal humoral immune response J:167119
absent CD4-positive, alpha-beta T cells J:167119
absent CD8-positive, alpha-beta T cells J:167119
decreased IgG level J:185495
decreased T cell number J:185495
normal immune system phenotype J:167119, J:185495
\Zap70m1Saka/\Zap70+
involves: BALB/c 		no abnormal phenotype detected J:86607
\Zap70m1Saka/\Zap70m1Saka
involves: BALB/c 		abnormal lymph node cell ratio J:154166
abnormal positive T cell selection J:86607, J:154166
abnormal splenic cell ratio J:154166
abnormal T cell clonal deletion J:154166
abnormal T cell differentiation J:86607
abnormal T cell selection J:86607
abnormal thymocyte activation J:154166
abnormal thymus cell ratio J:154166
chronic joint inflammation J:86607
decreased CD4-positive, alpha-beta T cell number J:86607, J:154166
decreased CD8-positive, alpha-beta T cell number J:86607, J:154166
decreased interleukin-2 secretion J:154166
decreased regulatory T cell number J:154166
decreased T cell proliferation J:86607, J:154166
fused joints J:86607
increased activated T cell number J:154166
increased autoantibody level J:86607
increased B cell number J:86607
increased immunoglobulin level J:86607
increased interleukin-17 secretion J:154166
increased memory T cell number J:154166
increased susceptibility to induced arthritis J:154166
joint dislocation J:86607
joint swelling J:86607
lung inflammation J:86607
mixed cellular infiltration to dermis J:86607
osteoporosis J:86607
rheumatoid arthritis J:86607
\Zap70m1Saka/\Zap70tm1Dlo
involves: 129P2/OlaHsd * BALB/c 		autoimmune arthritis J:86607
\Zap70m1Saka/\Zap70tm2.1Weis
involves: 129S4/SvJae * BALB/c 		abnormal T cell clonal deletion J:154166
decreased susceptibility to induced arthritis J:154166
\Zap70m2Btlr/\Zap70m2Btlr
involves: C57BL/6J 		decreased T cell number J:174837
\Zap70m3Btlr/\Zap70m3Btlr
C57BL/6J-Zap70m3Btlr 		decreased IgG level J:225043
impaired humoral immune response J:225043
\Zap70m4Btlr/\Zap70m4Btlr
C57BL/6J-Zap70m4Btlr 		decreased CD4-positive, alpha-beta T cell number J:236698
decreased CD8-positive, alpha-beta T cell number J:236698
decreased T cell number J:236698
impaired hematopoiesis J:236698
\Zap70m5Btlr/\Zap70m5Btlr
C57BL/6J-Zap70m5Btlr 		abnormal humoral immune response J:254830
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254830
decreased CD8-positive, alpha-beta T cell number J:254830
decreased CD8-positive, naive alpha-beta T cell number J:254830
decreased IgG level J:254830
increased B cell number J:254830
increased central memory CD4-positive, alpha-beta T cell number J:254830
increased central memory CD8 positive, alpha-beta T cell number J:254830
increased effector memory CD4-positive, alpha-beta T cell number J:254830
\Zap70m6Btlr/\Zap70m6Btlr
C57BL/6J-Zap70m6Btlr 		abnormal humoral immune response J:254831
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254831
decreased CD8-positive, alpha-beta T cell number J:254831
decreased CD8-positive, naive alpha-beta T cell number J:254831
decreased IgG level J:254831
increased B cell number J:254831
increased central memory CD4-positive, alpha-beta T cell number J:254831
increased central memory CD8 positive, alpha-beta T cell number J:254831
increased effector memory CD4-positive, alpha-beta T cell number J:254831
\Zap70m6Hefl/\Zap70m6Hefl
C3HeB/FeJ-Zap70m6Hefl 		abnormal humoral immune response J:137446
abnormal T cell differentiation J:137446
decreased CD4-positive, alpha-beta T cell number J:137446
decreased CD8-positive, alpha-beta T cell number J:137446
decreased T cell number J:137446
normal immune system phenotype J:137446
increased IgE level J:137446
increased IgG1 level J:137446
\Zap70m6Hefl/\Zap70tm1Weis
involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2 		decreased T cell number J:137446
increased IgE level J:137446
\Zap70m7Btlr/\Zap70m7Btlr
C57BL/6J-Zap70m7Btlr 		abnormal humoral immune response J:254832
decreased IgG level J:254832
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254832
increased central memory CD8 positive, alpha-beta T cell number J:254832
\Zap70m8Btlr/\Zap70m8Btlr
C57BL/6J-Zap70m8Btlr 		decreased CD8-positive, naive alpha-beta T cell number J:272864
increased central memory CD8 positive, alpha-beta T cell number J:272864
\Zap70mrtle/\Zap70mrtle
C57BL/6JSfdAnu-Zap70mrtle/Apb 		abnormal positive T cell selection J:104190
abnormal T cell subpopulation ratio J:104190
absent T cells J:104190
arrested T cell differentiation J:104190
decreased T cell number J:104190
\Zap70mrtle/\Zap70mrtle
involves: C57BL/6JSfdAnu 		abnormal double-positive T cell morphology J:211510
abnormal regulatory T cell number J:211510
decreased CD4-positive, alpha-beta T cell number J:211510
decreased CD8-positive, alpha-beta T cell number J:211510
increased double-positive T cell number J:211510
\Zap70mrtle/\Zap70rps
involves: C57BL/6 * C57BL/6JSfdAnu 		abnormal CD4-positive, alpha beta T cell morphology J:211510
abnormal double-positive T cell morphology J:211510
abnormal regulatory T cell number J:211510
decreased CD4-positive, alpha-beta T cell number J:211510
decreased CD8-positive, alpha-beta T cell number J:211510
increased double-positive T cell number J:211510
\Zap70mur/\Zap70mur
C57BL/6Apb-Zap70mur/ApbH 		abnormal T cell activation J:104190
abnormal T cell physiology J:104190
decreased T cell number J:104190
increased IgG2b level J:104190
\Zap70st/\Zap70st
involves: C57BL/6 		abnormal T cell physiology J:41170
arrested T cell differentiation J:41170
decreased T cell number J:41170
thymus hypoplasia J:41170
\Zap70st/\Zap70tm1Dlo
involves: C57BL/6 		arrested T cell differentiation J:41170
\Zap70tm1.1Mmal/\Zap70tm1.1Mmal
B6.129P2-Zap70tm1.1Mmal 		normal immune system phenotype J:71099
\Zap70tm1Dlo/\Zap70tm1Dlo
involves: 129P2/OlaHsd 		increased double-positive T cell number J:97610
\Zap70tm1Weis/\Zap70tm1Weis
involves: 129X1/SvJ * C57BL/6J 		abnormal lymph node cell ratio J:74974
abnormal splenic cell ratio J:74974
abnormal T cell differentiation J:74974
arrested T cell differentiation J:74974
small lymph nodes J:74974
\Zap70tm2.1Mmal/\Zap70tm2.1Mmal
B6.129P2-Zap70tm2.1Mmal 		normal immune system phenotype J:71099
\Zap70tm2.1Weis/\Zap70tm2.1Weis
B6.129S4-Zap70tm2.1Weis 		abnormal CD8-positive, alpha-beta T cell differentiation J:154166
abnormal thymus cell ratio J:154166
decreased CD4-positive, alpha-beta T cell number J:154166
decreased CD8-positive, alpha-beta T cell number J:154166
\Zap70tm2.1Weis/\Zap70tm2.1Weis
C.129S4-Zap70tm2.1Weis 		abnormal lymph node cell ratio J:154166
abnormal positive T cell selection J:154166
abnormal regulatory T cell physiology J:154166
abnormal splenic cell ratio J:154166
abnormal T cell clonal deletion J:154166
abnormal thymocyte activation J:154166
abnormal thymus cell ratio J:154166
decreased CD4-positive, alpha-beta T cell number J:154166
decreased CD8-positive, alpha-beta T cell number J:154166
decreased interleukin-2 secretion J:154166
decreased regulatory T cell number J:154166
decreased T cell proliferation J:154166
normal immune system phenotype J:154166
increased activated T cell number J:154166
increased interleukin-17 secretion J:154166
increased memory T cell number J:154166
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory