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Tyms Gene Detail
Summary
  • Symbol
    Tyms
  • Name
    thymidylate synthase
  • Synonyms
    TS
  • Feature Type
    protein coding gene
  • IDs
    MGI:98878
    NCBI Gene: 22171
  • Gene Overview
    MyGene.info: TYMS
Location & Maps
more
  • Sequence Map
    Chr5:30058202-30073617 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 15.81 cM
  • Mapping Data
    1 experiment
  • Sequence Tag
Homology
more
  • Human Ortholog
    TYMS, thymidylate synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TYMS, thymidylate synthetase
    Orthology source: HomoloGene
  • Synonyms
    HST422, TMS, TS
  • Links
    NCBI Gene ID: 7298
    neXtProt AC: NX_P04818

  • Chr Location
    18p11.32; chr18:657604-673499 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Gene trapped
    11
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    7 involving Tyms
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024722 VEGA Gene Model | MGI Sequence Detail 15416 C57BL/6J ±  kb
transcript OTTMUST00000060854 VEGA | MGI Sequence Detail 3163 Not Applicable  
polypeptide OTTMUSP00000029744 VEGA | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    135 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    Genomic 8
    cDNA 59
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15313
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 3
    Phenotypes 26
  • Earliest
    J:32323 Geyer PK, et al., Molecular cloning of DNA sequences complementary to mouse thymidylate synthase messenger RNA. J Biol Chem. 1984 Jun 10;259(11):7206-11
  • Latest
    J:215358 Cecchini MJ, et al., A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol. 2014 Jun;34(11):2029-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory