Thrb
Gene Detail

Symbol Name ID

Thrb thyroid hormone receptor beta MGI:98743

Synonyms

c-erbAbeta, Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, TR beta

Feature Type

protein coding gene

Genetic Map

Chromosome 14

7.08 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:17660960-18038086 bp, + strand From VEGA annotation of GRCm38   377127 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thyroid hormone receptor
Gene Tree: Thrb

Human homologs

Human Homolog		THRB, thyroid hormone receptor, beta
NCBI Gene ID		7068
neXtProt AC		NX_P10828
Human Synonyms		C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Human Chr (Location)		3p24.2; chr3:24158644-24536313 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human THRB

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Mice homozygous for a knock-out allele exhibit elevated T3, T4, and TSH serum levels, abnormal ear morphology, deafness, and abnormal thyroid morphology. Mice homozygous for allele with point mutations exhibit disruption in thyroid hormone sensitivity.

 
Human Diseases Modeled Using Mouse Thrb (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	female courtship behavior, intracellular receptor signaling pathway, ...
Component	nucleus
Function	chromatin DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (81)    Tissues (36)    Images (22)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	38
Northern blot	12
RT-PCR	31

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(5) cDNA(18) Primer pair(5) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023243 (Evidence)
Ensembl Gene Model	ENSMUSG00000021779 (Evidence)
Entrez Gene	21834 (Evidence)
DFCI	TC1589406, TC1628881
DoTS	DT.40179527, DT.523669
NIA Mouse Gene Index	U043380
Consensus CDS Project	CCDS26835.1, CCDS49404.1
International Mouse Knockout Project Status	Thrb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023243	VEGA Gene Model | MGI Sequence Detail	377127	C57BL/6J
transcript	OTTMUST00000056280	VEGA | MGI Sequence Detail	6081	Not Applicable
polypeptide	OTTMUSP00000027025	VEGA | MGI Sequence Detail	475	Not Applicable

All sequences(42) RefSeq(4) UniProt(3)

Polymorphisms

SNPs within 2kb(3033 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3043)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR001728	Thyroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000016321	thyroid hormone receptor beta

References

(Earliest) J:2023 Issemann I, et al., Cloning of novel members of the steroid hormone receptor superfamily. J Steroid Biochem Mol Biol. 1991;40(1-3):263-9
(Latest) J:201772 Kim WG, et al., Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model. Endocrinology. 2013 Aug;154(8):2936-47
All references(223)

Other accession IDs

MGD-MRK-15094, MGD-MRK-15095, MGD-MRK-15096