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Thrb Gene Detail
Summary
  • Symbol
    Thrb
  • Name
    thyroid hormone receptor beta
  • Synonyms
    c-erbAbeta, Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, TR beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:98743
    NCBI Gene: 21834
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
  • Regulated by
    Rr468 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr14:4431611-4809435 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10053 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98743
 protein coding gene Chr14:4429599-4810538 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021018
 protein coding gene Chr14:10256355-10650226 (+)
A/J MGP_AJ_G0020966
 protein coding gene Chr14:9949035-10334101 (+)
AKR/J MGP_AKRJ_G0020943
 protein coding gene Chr14:10254945-10646602 (+)
BALB/cJ MGP_BALBcJ_G0020969
 protein coding gene Chr14:10018117-10398178 (+)
C3H/HeJ MGP_C3HHeJ_G0020753
 protein coding gene Chr14:10314539-10730409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021402
 protein coding gene Chr14:10614971-11021295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018971
 protein coding gene Chr14:10495386-10882631 (+)
CAST/EiJ MGP_CASTEiJ_G0020276
 protein coding gene Chr14:10228001-10622035 (+)
CBA/J MGP_CBAJ_G0020719
 protein coding gene Chr14:11061577-11499041 (+)
DBA/2J MGP_DBA2J_G0020843
 protein coding gene Chr14:9860943-10243621 (+)
FVB/NJ MGP_FVBNJ_G0020825
 protein coding gene Chr14:9746159-10118622 (+)
LP/J MGP_LPJ_G0020918
 protein coding gene Chr14:10302914-10700451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020851
 protein coding gene Chr14:10946805-11364714 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021435
 protein coding gene Chr14:10143793-10529808 (+)
PWK/PhJ MGP_PWKPhJ_G0020027
 protein coding gene Chr14:9904381-10295331 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019848
 protein coding gene Chr14:10333205-10711398 (+)
WSB/EiJ MGP_WSBEiJ_G0020333
 protein coding gene Chr14:10197973-10602301 (+)



Homology
more
  • Human Ortholog
    THRB, thyroid hormone receptor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THRB, thyroid hormone receptor beta
  • Synonyms
    C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta, THRbeta1, Thrbeta2, TRb, TRbeta, TRbeta1
  • Links
    NCBI Gene ID: 7068
    UniProt: P10828

  • Chr Location
    3p24.2; chr3:24117153-24495756 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Thrb mouse models; 6 with human THRB associations

Human Disease Mouse Models
      
IDs
 View 10 models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    112 phenotypes from 13 alleles in 18 genetic backgrounds
    47 phenotypes from multigenic genotypes
    2 images
    201 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit elevated T3, T4, and TSH serum levels, abnormal ear morphology, deafness, and abnormal thyroid morphology. Mice homozygous for allele with point mutations exhibit disruption in thyroid hormone sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    77
  • cDNA Data
    19
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021779 Ensembl Gene Model | MGI Sequence Detail 377825 C57BL/6J ±  kb
    transcript ENSMUST00000022304 Ensembl | MGI Sequence Detail 6195 Not Applicable  
    polypeptide ENSMUSP00000022304 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 5
      cDNA 20
      Primer pair 14
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15094, MGD-MRK-15095, MGD-MRK-15096
    References
    more
    • Summaries
      All 335
      Developmental Gene Expression 67
      Diseases 9
      Gene Ontology 28
      Phenotypes 201
    • Earliest
      J:2023 Issemann I, et al., Cloning of novel members of the steroid hormone receptor superfamily. J Steroid Biochem Mol Biol. 1991;40(1-3):263-9
    • Latest
      J:364538 Ma X, et al., Thyroid hormone signaling is essential for the maturation and survival of cochlear root cells in mice. Hear Res. 2025 Apr;459:109222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory