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Thrb Gene Detail
Summary
  • Symbol
    Thrb
  • Name
    thyroid hormone receptor beta
  • Synonyms
    c-erbAbeta, Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, TR beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:98743
    NCBI Gene: 21834
  • Gene Overview
    MyGene.info: THRB
Location & Maps
more
  • Sequence Map
    Chr14:17660960-18038086 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      377127 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    THRB, thyroid hormone receptor beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THRB, thyroid hormone receptor beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
  • Links
    NCBI Gene ID: 7068
    neXtProt AC: NX_P10828

  • Chr Location
    3p24.2; chr3:24117153-24495281 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    3 with Thrb mouse models; 3 with human THRB associations

Human Disease Mouse Models
       Thyroid Hormone Resistance, Generalized, Autosomal Dominant; GRTH   OMIM: 188570 View 7 models
Thyroid Hormone Resistance, Generalized, Autosomal Recessive; GRTH   OMIM: 274300 View 2 models
       Attention Deficit-Hyperactivity Disorder; ADHD   OMIM: 143465 View 2 models
       Thyroid Hormone Resistance, Selective Pituitary; PRTH   OMIM: 145650
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    109 phenotypes from 13 alleles in 17 genetic backgrounds
    56 phenotypes from multigenic genotypes
    2 images
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit elevated T3, T4, and TSH serum levels, abnormal ear morphology, deafness, and abnormal thyroid morphology. Mice homozygous for allele with point mutations exhibit disruption in thyroid hormone sensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    132
  • Tissues
    53
  • cDNA Data
    18
  • Literature Summary
    44
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023243 VEGA Gene Model | MGI Sequence Detail 377127 C57BL/6J ±  kb
transcript OTTMUST00000056280 VEGA | MGI Sequence Detail 6081 Not Applicable  
polypeptide OTTMUSP00000027025 VEGA | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3005 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016321 thyroid hormone receptor beta
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR001728 Thyroid hormone receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 32
    Genomic 5
    cDNA 19
    Primer pair 6
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15094, MGD-MRK-15095, MGD-MRK-15096
References
more
  • Summaries
    All 248
    Developmental Gene Expression 44
    Diseases 10
    Gene Ontology 20
    Phenotypes 158
  • Earliest
    J:2023 Issemann I, et al., Cloning of novel members of the steroid hormone receptor superfamily. J Steroid Biochem Mol Biol. 1991;40(1-3):263-9
  • Latest
    J:234095 Alonso-Merino E, et al., Thyroid hormones inhibit TGF-beta signaling and attenuate fibrotic responses. Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3451-60
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory