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Thrb
Gene Detail
Symbol

Name
ID
Thrb
thyroid hormone receptor beta
MGI:98743
Synonyms
c-erbAbeta, Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, TR beta
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:17660960-18038086 bp, + strand
From VEGA annotation of GRCm38

  377127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: THRB
Protein SuperFamily: thyroid hormone receptor
Gene Tree: Thrb

Human
homologs
THRB, thyroid hormone receptor, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7068
neXtProt AC: NX_P10828

Human Synonyms: C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2

Human Chr (Location): 3p24.2; chr3:24117153-24495281 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human THRB

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Targeted(15) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit elevated T3, T4, and TSH serum levels, abnormal ear morphology, deafness, and abnormal thyroid morphology. Mice homozygous for allele with point mutations exhibit disruption in thyroid hormone sensitivity.
 
Human Diseases Modeled in Mice Using Thrb (4)    Mutations Annotated to Human Diseases (6)    Phenotype Images(2)
Interactions
Thrb interacts with 453 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process female courtship behavior, intracellular receptor signaling pathway, ...
Component extracellular exosome, nuclear chromatin, ...
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (106)    Tissues (48)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 12
RT-PCR 49
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA THRB ; Xenbase thrb ; ZFIN thrb    NEW 
Molecular
reagents
All nucleic(32) Genomic(5) cDNA(19) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023243 (Evidence)
Ensembl Gene Model ENSMUSG00000021779 (Evidence)
Entrez Gene 21834 (Evidence)
DFCI TC1589406, TC1628881
DoTS DT.40179527, DT.523669
NIA Mouse Gene Index U043380
Consensus CDS Project CCDS26835.1, CCDS49404.1
International Mouse Phenotyping Consortium Status Thrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023243 VEGA Gene Model | MGI Sequence Detail 377127 C57BL/6J ±  kb
transcript OTTMUST00000056280 VEGA | MGI Sequence Detail 6081 Not Applicable 
polypeptide OTTMUSP00000027025 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(34) UniProt(3)
Polymorphisms
SNPs within 2kb(3033 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3043)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000016321 thyroid hormone receptor beta
References
(Earliest) J:2023 Issemann I, et al., Cloning of novel members of the steroid hormone receptor superfamily. J Steroid Biochem Mol Biol. 1991;40(1-3):263-9
(Latest) J:222168 Huang CC, et al., A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-beta1. Endocrinology. 2015 Jun;156(6):2338-48
All references(238)
Disease annotation references (13)
Other
accession IDs
MGD-MRK-15094, MGD-MRK-15095, MGD-MRK-15096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory