Phenotypes Associated with This Genotype

Genotype
MGI:3588063

• Allelic Composition: Thrb^tm2Few/Thrb^tm2Few
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:77623 )

• learning deficit identified in a Morris water maze tes

nervous system

abnormal cerebellar Purkinje cell layer ( J:77623 )

• thin

abnormal Purkinje cell morphology ( J:77623 )

• reduced branching

decreased Purkinje cell number ( J:77623 )

thin cerebellar molecular layer ( J:77623 )

small cerebellum ( J:77623 )

• changes similar to those seen in congenital hypothyroidism

homeostasis/metabolism

increased thyroxine level ( J:77623 )

increased triiodothyronine level ( J:77623 )

increased circulating thyroid-stimulating hormone level ( J:77623 )

• 3 fold elevation over levels seen in Thrb^tm1Df homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:77623