Phenotypes Associated with This Genotype

Genotype
MGI:3715723

• Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92629 )

• 50% die by around 11 months of age and none survive beyond 16 months of age

endocrine/exocrine glands

increased thyroid gland weight ( J:92629 )

• weights of thyroid glands increase as mice age

increased thyroid carcinoma incidence ( J:92629 )

• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

neoplasm

increased thyroid carcinoma incidence ( J:92629 )

• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland follicular carcinoma		DOID:3962	OMIM:188470	J:92629