Tgm2
Gene Detail

Symbol Name ID

Tgm2 transglutaminase 2, C polypeptide MGI:98731

Synonyms

G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas

Feature Type

protein coding gene

Genetic Map

Chromosome 2

78.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:158116402-158146436 bp, - strand From VEGA annotation of GRCm38   30035 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm2

Human homologs

Human Homolog		TGM2, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
NCBI Gene ID		7052
neXtProt AC		NX_P21980
Human Synonyms		G-ALPHA-h, GNAH, TG2, TGC
Human Chr (Location)		20q12; chr20:36756863-36793700 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.

 
Human Diseases Modeled Using Mouse Tgm2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	apoptotic cell clearance, blood vessel remodeling, ...
Component	cytoplasm, cytosol, ...
Function	calcium ion binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (532)    Tissues (202)    Images (47)
Theiler Stages: 1, 2, 3, 4, 11, 12, 13, 14, 15, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	395
Northern blot	28
Western blot	14
RT-PCR	95

cDNA source data(202)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(215) Genomic(4) cDNA(203) Primer pair(8)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015888 (Evidence)
Ensembl Gene Model	ENSMUSG00000037820 (Evidence)
Entrez Gene	21817 (Evidence)
UniGene	330731
DFCI	TC1574009, TC1589261, TC1745888
DoTS	DT.101384679, DT.101389366, DT.101739099, DT.94288585, DT.94288607, DT.97416295
NIA Mouse Gene Index	U023589
EC	2.3.2.13
Consensus CDS Project	CCDS16985.1
International Mouse Knockout Project Status	Tgm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015888	VEGA Gene Model | MGI Sequence Detail	30035	C57BL/6J
transcript	OTTMUST00000037773	VEGA | MGI Sequence Detail	3596	Not Applicable
polypeptide	OTTMUSP00000016945	VEGA | MGI Sequence Detail	686	Not Applicable

All sequences(52) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(281 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR023608	Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro	IPR013808	Transglutaminase, conserved site
InterPro	IPR008958	Transglutaminase, C-terminal
InterPro	IPR002931	Transglutaminase-like
InterPro	IPR001102	Transglutaminase, N-terminal
Protein Ontology	PR:000016293	protein-glutamine gamma-glutamyltransferase 2

References

(Earliest) J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(108)

Other accession IDs

MGD-MRK-15073