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Tgm2 Gene Detail
Summary
  • Symbol
    Tgm2
  • Name
    transglutaminase 2, C polypeptide
  • Synonyms
    G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
  • Feature Type
    protein coding gene
  • IDs
    MGI:98731
    NCBI Gene: 21817
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157958325-157988312 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98731
protein coding gene Chr2:157958322-157988356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026789
protein coding gene Chr2:163172011-163201969 (-)
A/J MGP_AJ_G0026755
protein coding gene Chr2:156635515-156665527 (-)
AKR/J MGP_AKRJ_G0026726
protein coding gene Chr2:161255690-161285659 (-)
BALB/cJ MGP_BALBcJ_G0026764
protein coding gene Chr2:156937272-156968339 (-)
C3H/HeJ MGP_C3HHeJ_G0026506
protein coding gene Chr2:161563886-161595698 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027213
protein coding gene Chr2:168028970-168058899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024583
protein coding gene Chr2:150079074-150109078 (-)
CAST/EiJ MGP_CASTEiJ_G0025968
protein coding gene Chr2:161922787-161954250 (-)
CBA/J MGP_CBAJ_G0026483
protein coding gene Chr2:174063194-174093518 (-)
DBA/2J MGP_DBA2J_G0026621
protein coding gene Chr2:155808490-155838470 (-)
FVB/NJ MGP_FVBNJ_G0026588
protein coding gene Chr2:154210050-154241301 (-)
LP/J MGP_LPJ_G0026724
protein coding gene Chr2:163256514-163294135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026609
protein coding gene Chr2:177875360-177905265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027269
protein coding gene Chr2:161068987-161099965 (-)
PWK/PhJ MGP_PWKPhJ_G0025702
protein coding gene Chr2:155326810-155357213 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025505
protein coding gene Chr2:159996035-160025853 (-)
WSB/EiJ MGP_WSBEiJ_G0026038
protein coding gene Chr2:161970508-162001907 (-)



Homology
more
  • Human Ortholog
    TGM2, transglutaminase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGM2, transglutaminase 2
  • Synonyms
    G(h), hTG2, TGC, TG(C), tTG
  • Links
    NCBI Gene ID: 7052
    neXtProt AC: NX_P21980
    UniProt: P21980

  • Chr Location
    20q11.23; chr20:38127385-38168475 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Tgm2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21817 NCBI Gene Model | MGI Sequence Detail 29988 C57BL/6J ±  kb
    transcript NM_009373 RefSeq | MGI Sequence Detail 3549 ZRU/MplStud  
    polypeptide P21981 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 220
      Genomic 4
      cDNA 205
      Primer pair 10
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15073
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 23
      Diseases 3
      Gene Ontology 15
      Phenotypes 93
    • Earliest
      J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
    • Latest
      J:341155 Mizuno T, et al., Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury. Biochem Biophys Res Commun. 2023 Oct 20;678:179-185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory