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Tgm2 Gene Detail
Summary
  • Symbol
    Tgm2
  • Name
    transglutaminase 2, C polypeptide
  • Synonyms
    G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
  • Feature Type
    protein coding gene
  • IDs
    MGI:98731
    NCBI Gene: 21817
  • Gene Overview
    MyGene.info: TGM2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:158116402-158146436 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30035 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TGM2, transglutaminase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TGM2, transglutaminase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TGC, TG(C)
  • Links
    NCBI Gene ID: 7052
    neXtProt AC: NX_P21980
    UniProt: P21980

  • Chr Location
    20q11.23; chr20:38127387-38166578 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tgm2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015888 VEGA Gene Model | MGI Sequence Detail 30035 C57BL/6J ±  kb
    transcript OTTMUST00000037773 VEGA | MGI Sequence Detail 3596 Not Applicable  
    polypeptide OTTMUSP00000016945 VEGA | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      284 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 217
      Genomic 4
      cDNA 205
      Primer pair 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15073
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 9
      Phenotypes 64
    • Earliest
      J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
    • Latest
      J:264823 Rossin F, et al., TG2 regulates the heat-shock response by the post-translational modification of HSF1. EMBO Rep. 2018 Jul;19(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory