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Tgm2
Gene Detail
Symbol

Name
ID
Tgm2
transglutaminase 2, C polypeptide
MGI:98731
Synonyms
G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:158116402-158146436 bp, - strand
From VEGA annotation of GRCm38

  30035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGM2
Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm2

Human
homologs
TGM2, transglutaminase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7052
neXtProt AC: NX_P21980

Human Synonyms: G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC

Human Chr (Location): 20q12; chr20:38128461-38166509 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
 
Human Diseases Modeled in Mice Using Tgm2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tgm2 interacts with 161 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process apoptotic cell clearance, blood vessel remodeling, ...
Component cell, cytoplasm, ...
Function calcium ion binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (516)    Tissues (201)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 395
Northern blot 15
Western blot 14
RT-PCR 92
cDNA source data(203)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TGM2 ; Xenbase tgm2 ; ZFIN tgm2a, tgm2b    NEW 
Molecular
reagents
All nucleic(216) Genomic(4) cDNA(204) Primer pair(8)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015888 (Evidence)
Ensembl Gene Model ENSMUSG00000037820 (Evidence)
Entrez Gene 21817 (Evidence)
UniGene 330731
DFCI TC1574009, TC1589261, TC1745888
DoTS DT.101384679, DT.101389366, DT.101739099, DT.94288585, DT.94288607, DT.97416295
NIA Mouse Gene Index U023589
EC 2.3.2.13
Consensus CDS Project CCDS16985.1
International Mouse Phenotyping Consortium Status Tgm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015888 VEGA Gene Model | MGI Sequence Detail 30035 C57BL/6J ±  kb
transcript OTTMUST00000037773 VEGA | MGI Sequence Detail 3596 Not Applicable 
polypeptide OTTMUSP00000016945 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016293 protein-glutamine gamma-glutamyltransferase 2
References
(Earliest) J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
(Latest) J:216828 Menalled LB, et al., Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease. PLoS One. 2014;9(6):e99520
All references(121)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-15073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory