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Tcf4
Gene Detail
Symbol

Name
ID
Tcf4
transcription factor 4
MGI:98506
Synonyms
5730422P05Rik, ASP-I2, bHLHb19, E2-2, E2.2, ITF-2, ITF-2b, ME2, MITF-2A, MITF-2B, SEF-2, SEF2-1, TFE
Feature Type
protein coding gene
Genetic Map
Chromosome 18
43.23 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:69344146-69687925 bp, + strand
From VEGA annotation of GRCm38

  343780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2407  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf4

Human
homologs
Human Homolog TCF4, transcription factor 4
NCBI Gene ID 6925
neXtProt AC  NX_P15884
Human Synonyms  bHLHb19, E2-2, ITF2, ITF-2, PTHS, SEF2, SEF-2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4
Human Chr (Location)  18q21.1; chr18:55222331-55635957 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(24) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show a partial block in early thymopoiesis, increased double-negative T cell count, and increased sensitivity to anti-CD3 induced apoptosis. Homozygotes for another null allele show neonatal or postnatal lethality, reduced pro-B cell number, and abnormal pontine nuclei.
 
Interactions
Tcf4 interacts with 481 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell differentiation, DNA-templated transcription, initiation, ...
Component nucleus, transcription factor complex
Function bHLH transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (270)    Tissues (219)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 202
Northern blot 24
RT-PCR 44
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(41) Primer pair(4) Other(2)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021071 VEGA Gene Model | MGI Sequence Detail 343780 C57BL/6J ±  kb
transcript OTTMUST00000049864 VEGA | MGI Sequence Detail 4250 Not Applicable 
polypeptide OTTMUSP00000023178 VEGA | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(165) RefSeq(46) UniProt(15)
Polymorphisms
SNPs within 2kb(2160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016183 transcription factor 4
References
(Earliest) J:1499 Nielsen AL, et al., Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. Mol Cell Biol. 1992 Aug;12(8):3449-59
(Latest) J:212851 Meng Q, et al., Expression of signaling components in embryonic eyelid epithelium. PLoS One. 2014;9(2):e87038
All references(115)
Other
accession IDs
MGD-MRK-10807, MGD-MRK-14752, MGD-MRK-14758, MGI:1915012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory