Tcf4
Gene Detail

Symbol Name ID

Tcf4 transcription factor 4 MGI:98506

Synonyms

5730422P05Rik, ASP-I2, bHLHb19, E2-2, E2.2, ITF-2, ITF-2b, ME2, MITF-2A, MITF-2B, SEF-2, SEF2-1, TFE

Feature Type

protein coding gene

Genetic Map

Chromosome 18

43.23 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr18:69344146-69687925 bp, + strand From VEGA annotation of GRCm38   343780 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2407  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf4

Human homologs

Human Homolog		TCF4, transcription factor 4
NCBI Gene ID		6925
neXtProt AC		NX_P15884
Human Synonyms		bHLHb19, E2-2, ITF2, ITF-2, PTHS, SEF2, SEF-2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4
Human Chr (Location)		18q21.1; chr18:52889562-53303188 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TCF4

Alleles and phenotypes

All alleles(29) : Targeted(5) Gene trapped(24)
 

Homozygotes for a null allele show a partial block in early thymopoiesis, increased double-negative T cell count, and increased sensitivity to anti-CD3 induced apoptosis. Homozygotes for another null allele show neonatal or postnatal lethality, reduced pro-B cell number, and abnormal pontine nuclei.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cell differentiation, DNA-dependent transcription, initiation, ...
Component	nucleus, transcription factor complex
Function	bHLH transcription factor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (277)    Tissues (223)    Images (27)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	202
Northern blot	24
RT-PCR	51

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(1) cDNA(41) Primer pair(4) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021071 (Evidence)
Ensembl Gene Model	ENSMUSG00000053477 (Evidence)
Entrez Gene	21413 (Evidence)
DFCI	TC1574372, TC1587686, TC1590199, TC1592869, TC1601149, TC1613124, TC1670422
DoTS	DT.101328245, DT.101381864, DT.101381870, DT.101381871, DT.101381872, DT.101739066, DT.110772069, DT.492097, DT.91332981, DT.91427873, DT.94305247, DT.94314343, DT.97386507, DT.99686037
NIA Mouse Gene Index	U018867, U173038
Consensus CDS Project	CCDS29329.1, CCDS50315.1
International Mouse Knockout Project Status	Tcf4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021071	VEGA Gene Model | MGI Sequence Detail	343780	C57BL/6J
transcript	OTTMUST00000049864	VEGA | MGI Sequence Detail	4250	Not Applicable
polypeptide	OTTMUSP00000023178	VEGA | MGI Sequence Detail	692	Not Applicable

All sequences(116) RefSeq(4) UniProt(8)

Polymorphisms

SNPs within 2kb(2160 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000016183	transcription factor 4

References

(Earliest) J:1499 Nielsen AL, et al., Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. Mol Cell Biol. 1992 Aug;12(8):3449-59
(Latest) J:198628 Cai X, et al., Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
All references(111)

Other accession IDs

MGD-MRK-10807, MGD-MRK-14752, MGD-MRK-14758, MGI:1915012