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Tcf4
Gene Detail
Symbol

Name
ID
Tcf4
transcription factor 4
MGI:98506
Synonyms
5730422P05Rik, ASP-I2, bHLHb19, E2-2, E2.2, ITF-2, ITF-2b, ME2, MITF-2A, MITF-2B, SEF-2, SEF2-1, TFE
Feature Type
protein coding gene
Genetic Map
Chromosome 18
43.23 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:69344146-69687925 bp, + strand
From VEGA annotation of GRCm38

  343780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2407  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: TCF4
Protein SuperFamily: transcription factor 3
Gene Tree: Tcf4

Human
homologs
TCF4, transcription factor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6925
neXtProt AC: NX_P15884

Human Synonyms: bHLHb19, E2-2, ITF2, ITF-2, PTHS, SEF2, SEF-2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4

Human Chr (Location): 18q21.1; chr18:55222331-55635993 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TCF4

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(24) Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null allele show a partial block in early thymopoiesis, increased double-negative T cell count, and increased sensitivity to anti-CD3 induced apoptosis. Homozygotes for another null allele show neonatal or postnatal lethality, reduced pro-B cell number, and abnormal pontine nuclei.
 
Human Diseases Modeled in Mice Using Tcf4 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tcf4 interacts with 480 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell differentiation, DNA-templated transcription, initiation, ...
Component nucleus, transcription factor complex
Function bHLH transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (270)    Tissues (219)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 202
Northern blot 24
RT-PCR 44
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tcf4 ; ZFIN tcf4    NEW 
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(41) Primer pair(4) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021071 (Evidence)
Ensembl Gene Model ENSMUSG00000053477 (Evidence)
Entrez Gene 21413 (Evidence)
DFCI TC1574372, TC1587686, TC1590199, TC1592869, TC1601149, TC1613124, TC1670422
DoTS DT.101328245, DT.101381864, DT.101381870, DT.101381871, DT.101381872, DT.101739066, DT.110772069, DT.492097, DT.91332981, DT.91427873, DT.94305247, DT.94314343, DT.97386507, DT.99686037
NIA Mouse Gene Index U018867, U173038
Consensus CDS Project CCDS29329.1, CCDS50315.1
International Mouse Phenotyping Consortium Status Tcf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021071 VEGA Gene Model | MGI Sequence Detail 343780 C57BL/6J ±  kb
transcript OTTMUST00000049864 VEGA | MGI Sequence Detail 4250 Not Applicable 
polypeptide OTTMUSP00000023178 VEGA | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(150) RefSeq(38) UniProt(8)
Polymorphisms
SNPs within 2kb(2160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016183 transcription factor 4
References
(Earliest) J:1499 Nielsen AL, et al., Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. Mol Cell Biol. 1992 Aug;12(8):3449-59
(Latest) J:218701 Sisirak V, et al., Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J Exp Med. 2014 Sep 22;211(10):1969-76
All references(118)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10807, MGD-MRK-14752, MGD-MRK-14758, MGI:1915012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory