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Tcf4
Gene Detail
 Symbol
Name
ID
Tcf4
transcription factor 4
MGI:98506
Synonyms 5730422P05Rik, ASP-I2, bHLHb19, E2-2, E2.2, ITF-2, ITF-2b, ME2, MITF-2A, MITF-2B, SEF-2, SEF2-1, TFE
Feature Type protein coding gene
Genetic Map
Chromosome 18
43.23 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:69344146-69687925 bp, + strand
From VEGA annotation of GRCm38

  343780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2407  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf4

Human
homologs
Human Homolog TCF4, transcription factor 4
NCBI Gene ID 6925
neXtProt AC  NX_P15884
Human Synonyms  bHLHb19, E2-2, ITF2, ITF-2, PTHS, SEF2, SEF-2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4
Human Chr (Location)  18q21.1; chr18:55222331-55635957 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(24) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show a partial block in early thymopoiesis, increased double-negative T cell count, and increased sensitivity to anti-CD3 induced apoptosis. Homozygotes for another null allele show neonatal or postnatal lethality, reduced pro-B cell number, and abnormal pontine nuclei.
 
Interactions
Tcf4 interacts with 481 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell differentiation, DNA-templated transcription, initiation, ...
Component nucleus, transcription factor complex
Function bHLH transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (270)    Tissues (219)    Images (27)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 202
Northern blot 24
RT-PCR 44
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(41) Primer pair(4) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021071 (Evidence)
Ensembl Gene ModelENSMUSG00000053477 (Evidence)
Entrez Gene21413 (Evidence)
DFCITC1574372, TC1587686, TC1590199, TC1592869, TC1601149, TC1613124, TC1670422
DoTSDT.101328245, DT.101381864, DT.101381870, DT.101381871, DT.101381872, DT.101739066, DT.110772069, DT.492097, DT.91332981, DT.91427873, DT.94305247, DT.94314343, DT.97386507, DT.99686037
NIA Mouse Gene IndexU018867, U173038
Consensus CDS ProjectCCDS29329.1, CCDS50315.1
International Mouse Knockout Project StatusTcf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021071 VEGA Gene Model | MGI Sequence Detail 343780 C57BL/6J ±  kb
transcript OTTMUST00000049864 VEGA | MGI Sequence Detail 4250 Not Applicable 
polypeptide OTTMUSP00000023178 VEGA | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(158) RefSeq(46) UniProt(8)
Polymorphisms SNPs within 2kb(2160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016183 transcription factor 4
References (Earliest) J:1499 Nielsen AL, et al., Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. Mol Cell Biol. 1992 Aug;12(8):3449-59
(Latest) J:198628 Cai X, et al., Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
All references(112)
Other
accession IDs
MGD-MRK-10807, MGD-MRK-14752, MGD-MRK-14758, MGI:1915012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory