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Tap1
Gene Detail
Symbol

Name
ID
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98483
Synonyms
Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:34187553-34197225 bp, + strand
From VEGA annotation of GRCm38

  9673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TAP1
Protein SuperFamily: ABC-type transport system, bifunctional permease/ATPase, subfamily B
Gene Tree: Tap1

Human
homologs
TAP1, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6890
neXtProt AC: NX_Q03518

Human Synonyms: ABC17, ABCB2, APT1, D6S114E, PSF1, PSF-1, RING4, TAP1*0102N, TAP1N

Human Chr (Location): 6p21.3; chr6:32845209-32853971 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TAP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tap1 interacts with 72 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (109)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 142
RT-PCR 4
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488534    NEW 
Molecular
reagents
All nucleic(44) Genomic(14) cDNA(27) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036473 (Evidence)
Ensembl Gene Model ENSMUSG00000037321 (Evidence)
Entrez Gene 21354 (Evidence)
NIA Mouse Gene Index U017847
Consensus CDS Project CCDS28643.1, CCDS50072.1
International Mouse Phenotyping Consortium Status Tap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036473 VEGA Gene Model | MGI Sequence Detail 9673 C57BL/6J ±  kb
transcript OTTMUST00000093466 VEGA | MGI Sequence Detail 2953 Not Applicable 
polypeptide OTTMUSP00000051841 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013305 ABC transporter, ABCB2
InterPro IPR013306 ABC transporter, B3
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000016051 antigen peptide transporter 1
References
(Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:216144 Dixon-Salazar TJ, et al., MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling. J Neurosci. 2014 Aug 27;34(35):11844-56
All references(222)
Other
accession IDs
MGD-MRK-10612, MGD-MRK-10614, MGD-MRK-14712, MGD-MRK-14714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory