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Tap1 Gene Detail
Summary
  • Symbol
    Tap1
  • Name
    transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  • Synonyms
    Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98483
    NCBI Gene: 21354
  • Gene Overview
    MyGene.info: TAP1
Location & Maps
more
  • Sequence Map
    Chr17:34187553-34197225 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9673 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    TAP1, transporter 1, ATP binding cassette subfamily B member
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAP1, transporter 1, ATP binding cassette subfamily B member
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC17, ABCB2, APT1, D6S114E, PSF1, PSF-1, RING4, TAP1*0102N, TAP1N
  • Links
    NCBI Gene ID: 6890
    neXtProt AC: NX_Q03518

  • Chr Location
    6p21.32; chr6:32845209-32853971 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TAP1 associations

Human Disease Mouse Models
       Bare Lymphocyte Syndrome, Type I   OMIM: 604571
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    163 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    2
  • Targeted
    6
  • Incidental Mutations
    APF
Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036473 VEGA Gene Model | MGI Sequence Detail 9673 C57BL/6J ±  kb
transcript OTTMUST00000093466 VEGA | MGI Sequence Detail 2953 Not Applicable  
polypeptide OTTMUSP00000051841 VEGA | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 14
    cDNA 27
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10612, MGD-MRK-10614, MGD-MRK-14712, MGD-MRK-14714
References
more
  • Summaries
    All 230
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 10
    Phenotypes 163
  • Earliest
    J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
  • Latest
    J:231928 Tetruashvily MM, et al., Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction. Mol Cell Neurosci. 2016 Apr;72:34-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory