About   Help   FAQ
Tap1
Gene Detail
Symbol

Name
ID
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98483
Synonyms
Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:34187553-34197225 bp, + strand
From VEGA annotation of GRCm38

  9673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ABC-type transport system, bifunctional permease/ATPase, subfamily B
Gene Tree: Tap1

Human
homologs
Human Homolog TAP1, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
NCBI Gene ID 6890
neXtProt AC  NX_Q03518
Human Synonyms  ABC17, ABCB2, APT1, D6S114E, PSF1, PSF-1, RING4, TAP1*0102N, TAP1N
Human Chr (Location)  6p21.3; chr6:32845209-32853971 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TAP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tap1 interacts with 72 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (109)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 142
RT-PCR 4
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(14) cDNA(27) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036473 (Evidence)
Ensembl Gene ModelENSMUSG00000037321 (Evidence)
Entrez Gene21354 (Evidence)
NIA Mouse Gene IndexU017847
Consensus CDS ProjectCCDS28643.1, CCDS50072.1
International Mouse Knockout Project StatusTap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036473 VEGA Gene Model | MGI Sequence Detail 9673 C57BL/6J ±  kb
transcript OTTMUST00000093466 VEGA | MGI Sequence Detail 2953 Not Applicable 
polypeptide OTTMUSP00000051841 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013305 ABC transporter, ABCB2
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR005293 Antigen peptide transporter 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000016051 antigen peptide transporter 1
References
(Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:207761 Fu G, et al., Themis sets the signal threshold for positive and negative selection in T-cell development. Nature. 2013 Dec 19;504(7480):441-5
All references(221)
Other
accession IDs
MGD-MRK-10612, MGD-MRK-10614, MGD-MRK-14712, MGD-MRK-14714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory