Tap1
Gene Detail

Symbol Name ID

Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) MGI:98483

Synonyms

Abcb2, Ham1, Ham-1, MTP1, PSF-1, RING4, TAP, Tap-1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr17:34187553-34197225 bp, + strand From VEGA annotation of GRCm38   9673 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tap1

Human homologs

Human Homolog		TAP1, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
NCBI Gene ID		6890
neXtProt AC		NX_Q03518
Human Synonyms		ABC17, ABCB2, APT1, D6S114E, PSF1, PSF-1, RING4, TAP1*0102N, TAP1N
Human Chr (Location)		6p21.3; chr6:32812986-32821748 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TAP1

Alleles and phenotypes

All alleles(6) : Targeted(5) Chemically induced(1)
 

Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	antigen processing and presentation of endogenous peptide antigen via MHC class I, ATP catabolic process, ...
Component	endoplasmic reticulum, integral to endoplasmic reticulum membrane, ...
Function	ADP binding, ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (154)    Tissues (111)    Images (22)
Theiler Stages: 1, 2, 3, 4, 22, 23, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	142
RT-PCR	7

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(14) cDNA(27) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036473 (Evidence)
Ensembl Gene Model	ENSMUSG00000037321 (Evidence)
Entrez Gene	21354 (Evidence)
NIA Mouse Gene Index	U017847
Consensus CDS Project	CCDS28643.1, CCDS50072.1
International Mouse Knockout Project Status	Tap1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036473	VEGA Gene Model | MGI Sequence Detail	9673	C57BL/6J
transcript	OTTMUST00000093466	VEGA | MGI Sequence Detail	2953	Not Applicable
polypeptide	OTTMUSP00000051841	VEGA | MGI Sequence Detail	724	Not Applicable

All sequences(63) RefSeq(4) UniProt(10)

Polymorphisms

RFLP(1) : SNPs(175 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR013305	ABC transporter, ABCB2
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
InterPro	IPR005293	Antigen peptide transporter 2
Protein Ontology	PR:000016051	antigen peptide transporter 1

References

(Earliest) J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
(Latest) J:194608 Sehrawat S, et al., A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 2013 Feb 14;121(7):1145-56
All references(212)

Other accession IDs

MGD-MRK-10612, MGD-MRK-10614, MGD-MRK-14712, MGD-MRK-14714