Tap1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98483

20 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tap1^m1Btlr/Tap1^m1Btlr C57BL/6J-Tap1^m1Btlr	decreased CD8-positive, alpha-beta memory T cell number	J:254888
Tap1^m1Btlr/Tap1^m1Btlr C57BL/6J-Tap1^m1Btlr	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254888
Tap1^m2Btlr/Tap1^m2Btlr C57BL/6J-Tap1^m2Btlr	decreased CD8-positive, alpha-beta T cell number	J:236697
	impaired hematopoiesis	J:236697
	increased susceptibility to Herpesvirales infection	J:236697
Tap1^rose/Tap1^rose C57BL/6JAnu-Tap1^rose/AnuApb	decreased CD8-positive, alpha-beta T cell number	J:166104
Tap1^tm1Arp/Tap1^tm1Arp B6.129S2-Tap1^tm1Arp/J	decreased CD8-positive, alpha-beta T cell number	J:123934
	decreased susceptibility to bacterial infection	J:123934
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:123934
	increased T-helper 1 cell number	J:123934
Tap1^tm1Arp/Tap1^tm1Arp involves: 129S2/SvPas	abnormal antigen presentation via MHC class I	J:64349
	abnormal dendritic cell antigen presentation	J:64349
	decreased CD8-positive, alpha-beta T cell number	J:64177, J:64349
	decreased cytotoxic T cell cytolysis	J:64349
	decreased level of surface class I molecules	J:64177, J:64349
	defective assembly of class I molecules	J:64177
	defective intracellular transport of class I molecules	J:64177
Tap1^tm1Arp/Tap1^tm1Arp involves: 129S2/SvPas * C57BL/6	abnormal antigen presentation	J:122479
	abnormal dendritic cell antigen presentation	J:112436
	abnormal lymphocyte physiology	J:122479
	absent CD8-positive, alpha-beta T cells	J:3524
	decreased double-negative T cell number	J:3524
	decreased level of surface class I molecules	J:3524
	defective intracellular transport of class I molecules	J:3524
Tap1^tm1Hpl/Tap1^tm1Hpl either: (involves: 129S2/SvPas * 129/Ola) or (involves: 129S2/SvPas * FVB)	normal immune system phenotype	J:60782
Tap1^{tm2b(EUCOMM)Hmgu}/Tap1^{tm2b(EUCOMM)Hmgu} C57BL/6N-Tap1^{tm2b(EUCOMM)Hmgu}/Ieg	increased startle reflex	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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