Tap1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tap1^m2Btlr
• Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); mutation 2, Bruce Beutler
• MGI ID: MGI:5806457
• Synonyms: rose2
• Gene: Tap1 Location: Chr17:34406530-34416199 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tap1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to G transversion at base pair 34,194,941 (v38) on chromosome 17, or base pair 7,386 in the GenBank genomic region NC_000083. The mutation corresponds to residue 2,253 in the mRNA sequence NM_013683 (variant 1) within exon 10 of 11 total exons or residue 2,169 in the mRNA sequence NM_001161730 (variant 2) within exon 11 of 12 total exons. The mutation results in an aspartic acid (D) to glutamic acid (E) substitution at position 643 (D643E) in isoform 1 and a D to E substitution at position 615 (D615E) in isoform 2 of the protein. (J:236697)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tap1 Mutation: 55 strains or lines available

References

• Original: J:236697 Zhang D, et al., Mutagenetix entry for rose2. MGI Direct Data Submission. 2016
• All: 1 reference(s)