About   Help   FAQ
Sox3
Gene Detail
Symbol

Name
ID
Sox3
SRY (sex determining region Y)-box 3
MGI:98365
Synonyms
Sox-3
Feature Type
protein coding gene
Genetic Map
Chromosome X
33.66 cM, cytoband A7.3-B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:60891366-60893430 bp, - strand
From VEGA annotation of GRCm38

  2065 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4118  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sox3

Human
homologs
Human Homolog SOX3, SRY (sex determining region Y)-box 3
NCBI Gene ID 6658
neXtProt AC  NX_P41225
Human Synonyms  GHDX, MRGH, PHP, PHPX, SOXB
Human Chr (Location)  Xq27.1; chrX:140502987-140505060 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SOX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Sex determination is normal in both homozygous mutant female and hemizygous mutant male mice, however, gonadal and developmental defects are observed in both sexes.
 
Human Diseases Modeled Using Mouse Sox3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sox3 interacts with 89 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process face development, forebrain development, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (216)    Tissues (160)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 170
Northern blot 8
RT-PCR 21
RNase protection 13
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(19) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017611 (Evidence)
Ensembl Gene ModelENSMUSG00000045179 (Evidence)
Entrez Gene20675 (Evidence)
UniGene35784
DFCITC1598047
DoTSDT.528050
NIA Mouse Gene IndexU039416
Consensus CDS ProjectCCDS30161.2
International Mouse Knockout Project StatusSox3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017611 VEGA Gene Model | MGI Sequence Detail 2065 C57BL/6J ±  kb
transcript OTTMUST00000042794 VEGA | MGI Sequence Detail 2065 Not Applicable 
polypeptide OTTMUSP00000019219 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022097 Transcription factor SOX
Protein Ontology PR:000015428 transcription factor SOX-3
References
(Earliest) J:10645 Gubbay J, et al., A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments]. Nature. 1990 Jul 19;346(6281):245-50
(Latest) J:213579 Liao HF, et al., DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
All references(95)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14494, MGD-MRK-14504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory