Sox3
Gene Detail

Symbol Name ID

Sox3 SRY-box containing gene 3 MGI:98365

Synonyms

Sox-3

Feature Type

protein coding gene

Genetic Map

Chromosome X

33.66 cM, cytoband A7.3-B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:60891366-60893430 bp, - strand From VEGA annotation of GRCm38   2065 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4118  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox3

Human homologs

Human Homolog		SOX3, SRY (sex determining region Y)-box 3
NCBI Gene ID		6658
neXtProt AC		NX_P41225
Human Synonyms		GHDX, MRGH, PHP, PHPX, SOXB
Human Chr (Location)		Xq27.1; chrX:139585152-139587225 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SOX3

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Sex determination is normal in both homozygous mutant female and hemizygous mutant male mice, however, gonadal and developmental defects are observed in both sexes.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	face development, forebrain development, ...
Component	nucleus
Function	DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (42 records)
Data Summary: Results (222)    Tissues (164)    Images (57)
Theiler Stages: 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	170
Northern blot	8
RT-PCR	28
RNase protection	13

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(2) cDNA(19) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017611 (Evidence)
Ensembl Gene Model	ENSMUSG00000045179 (Evidence)
Entrez Gene	20675 (Evidence)
UniGene	35784
DFCI	TC1598047
DoTS	DT.528050
NIA Mouse Gene Index	U039416
Consensus CDS Project	CCDS30161.2
International Mouse Knockout Project Status	Sox3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017611	VEGA Gene Model | MGI Sequence Detail	2065	C57BL/6J
transcript	OTTMUST00000042794	VEGA | MGI Sequence Detail	2065	Not Applicable
polypeptide	OTTMUSP00000019219	VEGA | MGI Sequence Detail	450	Not Applicable

All sequences(24) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
InterPro	IPR022097	Transcription factor SOX
Protein Ontology	PR:000015428	transcription factor SOX-3

References

(Earliest) J:10645 Gubbay J, et al., A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments]. Nature. 1990 Jul 19;346(6281):245-50
(Latest) J:189004 Iwafuchi-Doi M, et al., Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
All references(84)

Other accession IDs

MGD-MRK-14494, MGD-MRK-14504