Sox3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sox3
SRY (sex determining region Y)-box 3
MGI:98365

50 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox3^tm1.1Lja/Y involves: 129S1/Sv * 129X1/SvJ	abnormal seminiferous tubule morphology	J:86431
	abnormal Sertoli cell morphology	J:86431
	abnormal spermatogenesis	J:86431
	abnormal tooth morphology	J:86431
	normal behavior/neurological phenotype	J:86431
	decreased body weight	J:86431
	decreased germ cell number	J:86431
	decreased testis weight	J:86431
	oligozoospermia	J:86431
Sox3^tm1.1Lja/Sox3^tm1.1Lja involves: 129S1/Sv * 129X1/SvJ	abnormal female reproductive system morphology	J:86431
	abnormal oocyte morphology	J:86431
	abnormal ovarian folliculogenesis	J:86431
	abnormal tooth morphology	J:86431
	normal behavior/neurological phenotype	J:86431
	decreased body weight	J:86431
	increased atretic ovarian follicle number	J:86431
	reduced female fertility	J:86431
Sox3^tm1Pqt/Y chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal adenohypophysis development	J:195300
	abnormal pituitary infundibular stalk morphology	J:195300
	absent pituitary infundibular stalk	J:195300
	normal cellular phenotype	J:195300
	normal embryo phenotype	J:195300
	male infertility	J:195300
Sox3^tm1Rlb/Sox3⁺ involves: 129S7/SvEvBrd * MF1	abnormal craniofacial morphology	J:88507
Sox3^tm1Rlb/Y involves: 129S7/SvEvBrd * MF1	abnormal brain commissure morphology	J:88507
	abnormal corpus callosum morphology	J:88507
	abnormal craniofacial morphology	J:88507
	abnormal diencephalon morphology	J:88507
	abnormal hippocampal commissure morphology	J:88507
	abnormal hypothalamus morphology	J:88507
	abnormal pituitary gland morphology	J:88507
	abnormal Rathke's pouch development	J:88507
	abnormal testis morphology	J:88507
	abnormal third ventricle morphology	J:88507
	bifurcated Rathke's pouch	J:88507
	decreased follicle stimulating hormone level	J:88507
	decreased growth hormone level	J:88507
	decreased thyroid-stimulating hormone level	J:88507
	postnatal growth retardation	J:88507
	postnatal lethality, incomplete penetrance	J:88507
Sox3^tm1Rlb/Sox3^tm1Rlb involves: 129S7/SvEvBrd * MF1	abnormal brain commissure morphology	J:88507
	abnormal corpus callosum morphology	J:88507
	abnormal diencephalon morphology	J:88507
	abnormal hippocampal commissure morphology	J:88507
	abnormal hypothalamus morphology	J:88507
	abnormal pituitary gland morphology	J:88507
	abnormal Rathke's pouch development	J:88507
	abnormal third ventricle morphology	J:88507
	bifurcated Rathke's pouch	J:88507
	increased atretic ovarian follicle number	J:88507
	postnatal lethality	J:88507
	normal reproductive system phenotype	J:88507
	small ovary	J:88507
Tg(Sox3)1Pqt/0 involves: C57BL/6 * CBA	hydrocephaly	J:184232
Tg(Sox3)1Pqt/0 Tg(Sox3-EGFP)NrPqt/0 involves: C57BL/6 * CBA	abnormal diencephalon morphology	J:184232
	abnormal posterior commissure morphology	J:184232
	abnormal roof plate morphology	J:184232
	abnormal subcommissural organ morphology	J:184232
	absent pineal gland	J:184232
	absent pineal recess	J:184232
	domed cranium	J:184232
	enlarged lateral ventricles	J:184232
	enlarged third ventricle	J:184232
	hydrocephaly	J:184232
	increased cell proliferation	J:184232
	normal nervous system phenotype	J:184232

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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