Sox3tm1Rlb
Targeted Allele Detail
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Symbol: |
Sox3tm1Rlb |
Name: |
SRY (sex determining region Y)-box 3; targeted mutation 1, Robin Lovell-Badge |
MGI ID: |
MGI:3036671 |
Synonyms: |
Sox3deltagfp |
Gene: |
Sox3 Location: ChrX:59934972-59937036 bp, - strand Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
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Alliance: |
Sox3tm1Rlb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:88507
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Other
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Mutation details: The endogenous coding region was replaced with a construct containing floxed Sox3 sequence followed by GFP and frt-flanked neo. The floxed Sox3 sequence was removed via cre-mediated recomibination in the germline, leaving GFP downstream of the endogenous promoter. Mutant XY embryos expressed GFP, but not Sox3, in a pattern consistent with that of endogenous Sox3 expression in wild-type mice.
This allele was derived from Sox3tm2Rlb
(J:88507)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sox3 Mutation: |
7 strains or lines available
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Original: |
J:88507 Rizzoti K, et al., SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat Genet. 2004 Mar;36(3):247-55 |
All: |
7 reference(s) |
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