Gene Expression Literature Summary

• Symbol: Sox3
• Name: SRY (sex determining region Y)-box 3
• ID: MGI:98365

78 matching records from 78 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E18	E18.5	E	P
Immunohistochemistry (section)									1		2		4		8	1	5		7	5	4	1	4	2	1	5		8
In situ RNA (section)									2	1	3	2	1		8		4		2	6	5		3	1		2	1	2
Immunohistochemistry (whole mount)									2		1		1															1
In situ RNA (whole mount)							1	2	2	3	3	2	3		5		1		1
In situ reporter (knock in)												1	1		1				1				1					1
Northern blot															1		1											1
RT-PCR	1	1	1	1	1	1	1		2				2	1	1	1	2	1	4	1	1		2	1		1		8
cDNA clones											1
RNase protection																	1											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox3  SRY (sex determining region Y)-box 3   (Synonyms: Sox-3)
Results	Reference
2*	J:181010 Acloque H, Ocana OH, Matheu A, Rizzoti K, Wise C, Lovell-Badge R, Nieto MA, Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell. 2011 Sep 13;21(3):546-58
4	J:246645 Adikusuma F, Pederick D, McAninch D, Hughes J, Thomas P, Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017 Jul;206(3):1495-1503
1	J:128347 Ahituv N, Zhu Y, Visel A, Holt A, Afzal V, Pennacchio LA, Rubin EM, Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007 Sep;5(9):e234
1	J:198458 Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schuller U, Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Res. 2013 Jun 15;73(12):3796-807
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4	J:101530 Bowl MR, Nesbit MA, Harding B, Levy E, Jefferson A, Volpi E, Rizzoti K, Lovell-Badge R, Schlessinger D, Whyte MP, Thakker RV, An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. J Clin Invest. 2005 Oct;115(10):2822-31
12*	J:31475 Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow PN, Lovell-Badge R, A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996 Feb;122(2):509-20
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:204443 Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP, CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell. 2013 Aug 12;26(3):223-36
1	J:99610 Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V, Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
1	J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
1	J:194843 Ferri A, Favaro R, Beccari L, Bertolini J, Mercurio S, Nieto-Lopez F, Verzeroli C, La Regina F, De Pietri Tonelli D, Ottolenghi S, Bovolenta P, Nicolis SK, Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh. Development. 2013 Mar;140(6):1250-61
1	J:155627 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S, SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1114-20
1	J:175526 Gomez-Lopez S, Wiskow O, Favaro R, Nicolis SK, Price DJ, Pollard SM, Smith A, Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia. 2011 Nov;59(11):1588-99
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
3	J:253782 Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A, Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Sci Rep. 2016 Jun 1;6:26448
5	J:206315 Hoffmann SA, Hos D, Kuspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S, Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014 Jan;141(1):39-50
2	J:123251 Holm PC, Mader MT, Haubst N, Wizenmann A, Sigvardsson M, Gotz M, Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci. 2007 Jan;34(1):99-119
3	J:195300 Hughes J, Piltz S, Rogers N, McAninch D, Rowley L, Thomas P, Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism. PLoS Genet. 2013 Mar;9(3):e1003290
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
2	J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
3*	J:278249 Iwafuchi-Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, Uchikawa M, Kamachi Y, Kondoh H, The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates. Dev Biol. 2011 Apr 15;352(2):354-66
1	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
1	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
5*	J:229536 Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, Maeda T, Hagiwara N, Que J, Sharpe PT, Ohazama A, Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59(10-12):471-8
1	J:137186 Kurimoto K, Yabuta Y, Ohinata Y, Shigeta M, Yamanaka K, Saitou M, Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice. Genes Dev. 2008 Jun 15;22(12):1617-35
2	J:244157 Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Blass G, Timmermann B, Herrmann BG, Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a. Biol Open. 2017 Jun 15;6(6):752-764
1	J:236825 Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, Mengus G, Davidson I, Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016 Mar 30;7:11063
2	J:185560 Lee B, Rizzoti K, Kwon DS, Kim SY, Oh S, Epstein DJ, Son Y, Yoon J, Baek K, Jeong Y, Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer. Dev Biol. 2012 Jun 15;366(2):393-403
2	J:200777 Lee B, Song H, Rizzoti K, Son Y, Yoon J, Baek K, Jeong Y, Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain. Dev Biol. 2013 Sep 15;381(2):491-501
6	J:184232 Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R, Thomas PQ, Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice. PLoS One. 2012;7(1):e29041
1*	J:329046 Li B, Brusman L, Dahlka J, Niswander LA, TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration. Development. 2022 Sep 1;149(17):dev200442
1	J:213579 Liao HF, Chen WS, Chen YH, Kao TH, Tseng YT, Lee CY, Chiu YC, Lee PL, Lin QJ, Ching YH, Hata K, Cheng WT, Tsai MH, Sasaki H, Ho HN, Wu SC, Huang YH, Yen P, Lin SP, DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
3*	J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1	J:156172 Marklund U, Hansson EM, Sundstrom E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J, Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45
1	J:221020 Martinez C, Cornejo VH, Lois P, Ellis T, Solis NP, Wainwright BJ, Palma V, Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source. PLoS One. 2013;8(6):e65818
1	J:138323 Miyagi S, Masui S, Niwa H, Saito T, Shimazaki T, Okano H, Nishimoto M, Muramatsu M, Iwama A, Okuda A, Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett. 2008 Aug 6;582(18):2811-5
2*	J:328290 Nakagawa T, Jorg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T, A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Rep. 2021 Oct 19;37(3):109875
1*	J:180596 Ohyama K, Yasuda K, Onga K, Kakizuka A, Mori N, Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: Implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Gene Expr Patterns. 2012 Jan;12(1-2):36-45
4*	J:255320 Pederick DT, Richards KL, Piltz SG, Kumar R, Mincheva-Tasheva S, Mandelstam SA, Dale RC, Scheffer IE, Gecz J, Petrou S, Hughes JN, Thomas PQ, Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron. 2018 Jan 3;97(1):59-66.e5
1	J:162001 Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ, NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. J Neurosci. 2010 Jul 7;30(27):9127-39
2	J:273632 Planells B, Gomez-Redondo I, Pericuesta E, Lonergan P, Gutierrez-Adan A, Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202
2*	J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96
3	J:99393 Raverot G, Weiss J, Park SY, Hurley L, Jameson JL, Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev Biol. 2005 Jul 1;283(1):215-25
7	J:88507 Rizzoti K, Brunelli S, Carmignac D, Thomas PQ, Robinson IC, Lovell-Badge R, SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat Genet. 2004 Mar;36(3):247-55
6	J:128002 Rizzoti K, Lovell-Badge R, SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007 Oct;134(19):3437-48
7*	J:199191 Rogers N, Cheah PS, Szarek E, Banerjee K, Schwartz J, Thomas P, Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expr Patterns. 2013 Oct;13(7):240-8
2	J:318367 Rraklli V, Sodersten E, Nyman U, Hagey DW, Holmberg J, Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming. Stem Cell Res. 2016 Jan;16(1):1-9
3	J:123685 Saarimaki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J, Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J Neurosci. 2007 Aug 8;27(32):8581-92
1	J:148018 Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K, Shiroishi T, A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
1	J:142649 Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP, Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech. 2008 Nov;1(4-5):241-54
1	J:124679 Schreiner S, Cossais F, Fischer K, Scholz S, Bosl MR, Holtmann B, Sendtner M, Wegner M, Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007 Sep;134(18):3271-81
3	J:175105 Shen JH, Ingraham HA, Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002 Mar;16(3):529-40
1	J:332291 Song H, Morrow BE, Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. Dev Biol. 2022 Dec 12;494:71-84
2	J:116148 Stolt CC, Schlierf A, Lommes P, Hillgartner S, Werner T, Kosian T, Sock E, Kessaris N, Richardson WD, Lefebvre V, Wegner M, SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006 Nov;11(5):697-709
1*	J:98585 Stolt CC, Schmitt S, Lommes P, Sock E, Wegner M, Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol. 2005 May 15;281(2):309-17
1*	J:324832 Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W, Liu Z, Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
2	J:171839 Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P, Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan 4;121(1):328-41
1	J:286609 Tait CM, Chinnaiya K, Manning E, Murtaza M, Ashton JP, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS, Furley A, Rashbass P, Das RM, Storey KG, Placzek M, Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal. PLoS Biol. 2020 Mar;18(3):e3000470
2	J:217059 Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H, Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
2	J:145841 Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, Kondoh H, Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol. 2004 Oct;24(20):8834-46
1	J:314040 Thomson E, Dawson R, H'ng CH, Adikusuma F, Piltz S, Thomas PQ, The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo development. PLoS One. 2021;16(11):e0258538
1*	J:143535 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J, Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol. 2009 Jan 1;325(1):238-48
1	J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1*	J:82084 Van de Putte T, Maruhashi M, Francis A, Nelles L, Kondoh H, Huylebroeck D, Higashi Y, Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet. 2003 Feb;72(2):465-70
1	J:223775 Vidovic D, Harris L, Harvey TJ, Evelyn Heng YH, Smith AG, Osinski J, Hughes J, Thomas P, Gronostajski RM, Bailey TL, Piper M, Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX. Brain Res. 2015 Aug 7;1616:71-87
1*	J:310323 Vied CM, Freudenberg F, Wang Y, Raposo AA, Feng D, Nowakowski RS, A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Front Neurosci. 2014;8:257
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3*	J:235366 Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, Nagai T, Kitamura A, Nishikawa A, Kodama Y, Takagi R, Maeda T, Sharpe PT, Ohazama A, Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016 Jul;21(2):111-8
2*	J:180986 Wei Q, Condie BG, A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795
9*	J:57065 Wood HB, Episkopou V, Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev. 1999 Aug;86(1-2):197-201
1	J:326525 Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J, PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 Feb 22;145(8):586-602
2	J:120909 Xu C, Fan CM, Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1. Mol Endocrinol. 2007 May;21(5):1234-45
1*	J:208424 Yoshida M, Uchikawa M, Rizzoti K, Lovell-Badge R, Takemoto T, Kondoh H, Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast. Mech Dev. 2014 May;132:59-68
1	J:254919 Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH, An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Elife. 2017 Nov 15;6:e30126
1	J:306263 Zhang YH, Xu M, Shi X, Sun XL, Mu W, Wu H, Wang J, Li S, Su P, Gong L, He M, Yao M, Wu QF, Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 2021 Apr 17;
1	J:182725 Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ, Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell. 2012 Mar 13;22(3):585-96
1	J:157264 Zhao Y, Mailloux CM, Hermesz E, Palkovits M, Westphal H, A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol. 2010 Jan 15;337(2):313-23