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Sos1 Gene Detail
Summary
  • Symbol
    Sos1
  • Name
    son of sevenless homolog 1 (Drosophila)
  • Synonyms
    4430401P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98354
    NCBI Gene: 20662
  • Gene Overview
    MyGene.info: SOS1
Location & Maps
more
  • Sequence Map
    Chr17:80393752-80480453 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86702 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 50.67 cM, cytoband C3-D
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GF1, GGF1, GINGF, HGF, NS4
  • Links
    NCBI Gene ID: 6654
    neXtProt AC: NX_Q07889

  • Chr Location
    2p22.1; chr2:38981549-39124744 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4117
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SOS1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sos1 mouse models; 2 with human SOS1 associations

Human Disease Mouse Models
       Noonan Syndrome 4; NS4   OMIM: 610733 View 2 models
       Fibromatosis, Gingival, 1; GINGF1   OMIM: 135300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    5 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant embryos exhibit placental and cardiovascular defects resulting in death around mid-gestation. When heterozygous, these mutations enhance the eye defects of homozygous mutants of the epidermal growth factor receptor gene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20662 NCBI Gene Model | MGI Sequence Detail 86702 C57BL/6J ±  kb
transcript NM_009231 RefSeq | MGI Sequence Detail 8919 C57BL/6  
polypeptide Q62245 UniProt | EBI | MGI Sequence Detail 1319 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    475 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 18
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-14489, MGI:1918028, MGI:2146862
References
more
  • Summaries
    All 77
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 21
    Phenotypes 24
  • Earliest
    J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
  • Latest
    J:229752 Guittard G, et al., Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration. Eur J Immunol. 2015 Aug;45(8):2389-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory