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Sos1
Gene Detail
 Symbol
Name
ID
Sos1
son of sevenless homolog 1 (Drosophila)
MGI:98354
Synonyms 4430401P03Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
50.67 cM, cytoband C3-D
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:80393752-80480453 bp, - strand
From NCBI annotation of GRCm38

  86702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Sos1

Human
homologs
Human Homolog SOS1, son of sevenless homolog 1 (Drosophila)
NCBI Gene ID 6654
neXtProt AC  NX_Q07889
Human Synonyms  GF1, GGF1, GINGF, HGF, NS4
Human Chr (Location)  2p21; chr2:38981549-39120543 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SOS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant embryos exhibit placental and cardiovascular defects resulting in death around mid-gestation. When heterozygous, these mutations enhance the eye defects of homozygous mutants of the epidermal growth factor receptor gene.
 
Human Diseases Modeled Using Mouse Sos1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Sos1 interacts with 450 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process fibroblast growth factor receptor signaling pathway, neurotrophin TRK receptor signaling pathway, ...
Component intracellular, neuronal cell body, ...
Function DNA binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (82)    Tissues (59)    Images (29)
Theiler Stages: 2, 3, 4, 5, 16, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 57
Northern blot 19
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024241 (Evidence)
Entrez Gene20662 (Evidence)
PDB1GBQ, 1PMS, 2GBQ, 3GBQ, 4GBQ, 1B07
Consensus CDS ProjectCCDS37704.1
International Mouse Knockout Project StatusSos1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20662 NCBI Gene Model | MGI Sequence Detail 86702 C57BL/6J ±  kb
transcript NM_009231 RefSeq | MGI Sequence Detail 8919 C57BL/6 
polypeptide Q62245 UniProt | EBI | MGI Sequence Detail 1319 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(483 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR007125 Histone core
InterPro IPR009072 Histone-fold
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR019804 Ras guanine-nucleotide exchange factor, conserved site
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology PR:000015413 son of sevenless homolog 1
Graphical View of Protein Domain Structure
References (Earliest) J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
(Latest) J:206901 Findlay GM, et al., Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013 Feb 28;152(5):1008-20
All references(76)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14489, MGI:1918028, MGI:2146862

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory