Sos1
Gene Detail

Symbol Name ID

Sos1 son of sevenless homolog 1 (Drosophila) MGI:98354

Synonyms

4430401P03Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

50.67 cM, cytoband C3-D
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr17:80393752-80480453 bp, - strand From NCBI annotation of GRCm38   86702 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Sos1

Human homologs

Human Homolog		SOS1, son of sevenless homolog 1 (Drosophila)
NCBI Gene ID		6654
neXtProt AC		NX_Q07889
Human Synonyms		GF1, GGF1, GINGF, HGF, NS4
Human Chr (Location)		2p21; chr2:39208690-39347604 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SOS1

Alleles and phenotypes

All alleles(29) : Targeted(6) Gene trapped(23)
 

Homozygous null mutant embryos exhibit placental and cardiovascular defects resulting in death around mid-gestation. When heterozygous, these mutations enhance the eye defects of homozygous mutants of the epidermal growth factor receptor gene.

 
Human Diseases Modeled Using Mouse Sos1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	fibroblast growth factor receptor signaling pathway, neurotrophin TRK receptor signaling pathway, ...
Component	intracellular, neuronal cell body, ...
Function	DNA binding, guanyl-nucleotide exchange factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (85)    Tissues (62)    Images (29)
Theiler Stages: 2, 3, 4, 5, 16, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	57
Northern blot	19
RT-PCR	7

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(18) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024241 (Evidence)
Entrez Gene	20662 (Evidence)
PDB	1GBQ, 1PMS, 2GBQ, 3GBQ, 4GBQ
Consensus CDS Project	CCDS37704.1
International Mouse Knockout Project Status	Sos1

Sequences

Length	Strain/Species
genomic	20662	NCBI Gene Model | MGI Sequence Detail	86702	C57BL/6J
transcript	NM_009231	RefSeq | MGI Sequence Detail	8919	C57BL/6
polypeptide	Q62245	UniProt | EBI | MGI Sequence Detail	1319	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(454 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001895	Guanine-nucleotide dissociation stimulator CDC25
InterPro	IPR007125	Histone core
InterPro	IPR009072	Histone-fold
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR015759	Ras GTP exchange factor, son of sevenless
InterPro	IPR008937	Ras guanine nucleotide exchange factor
InterPro	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
InterPro	IPR023578	Ras guanine nucleotide exchange factor, domain
InterPro	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology	PR:000015413	son of sevenless 1

Graphical View of Protein Domain Structure

References

(Earliest) J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
(Latest) J:190827 Kortum RL, et al., A Phospholipase C-gamma1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice. J Immunol. 2013 Jan 1;190(1):147-58
All references(67)

Other accession IDs

MGD-MRK-14489, MGI:1918028, MGI:2146862