Sos1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Egfr^wa2/Egfr^wa2 Sos1^tm1Dlb/Sos1⁺ involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfr^wa2 Wnt3a^vt	abnormal ciliary body morphology	J:38321
	abnormal cornea morphology	J:38321
	abnormal eye anterior chamber morphology	J:38321
	abnormal lens fiber morphology	J:38321
	abnormal retina morphology	J:38321
	anterior iris synechia	J:38321
	cornea opacity	J:38321
	cornea vascularization	J:38321
	eyelids open at birth	J:38321
	fused cornea and lens	J:38321
	increased cornea thickness	J:38321
	lens vacuoles	J:38321
	microphthalmia	J:38321
	preweaning lethality, incomplete penetrance	J:38321
	small lens	J:38321
Rag2^tm1Fwa/Rag2^tm1Fwa Sos1^tm1.1Les/Sos1^tm1.1Les Tg(Lck-cre)1Cwi/0 involves: 129S/SvEv * C57BL/6	abnormal T cell differentiation	J:174536
	decreased T cell proliferation	J:174536

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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