Sos1 Phenotype Annotations - Multigenic Genotypes

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Egfr^wa2/Egfr^wa2 Sos1^tm1Dlb/Sos1⁺ involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfr^wa2 Wnt3a^vt	abnormal ciliary body morphology	J:38321
	abnormal cornea morphology	J:38321
	abnormal eye anterior chamber morphology	J:38321
	abnormal lens fiber morphology	J:38321
	abnormal retina morphology	J:38321
	anterior iris synechia	J:38321
	corneal opacity	J:38321
	corneal vascularization	J:38321
	eyelids open at birth	J:38321
	fused cornea and lens	J:38321
	increased cornea thickness	J:38321
	lens vacuoles	J:38321
	microphthalmia	J:38321
	preweaning lethality, incomplete penetrance	J:38321
	small lens	J:38321
Rag2^tm1Fwa/Rag2^tm1Fwa Sos1^tm1.1Les/Sos1^tm1.1Les Tg(Lck-cre)1Cwi/0 involves: 129S/SvEv * C57BL/6	abnormal T cell differentiation	J:174536
	decreased T cell proliferation	J:174536

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23