64 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sos1tm1.1Les/Sos1tm1.1Les Tg(Lck-cre)1Cwi/0 involves: 129 * C57BL/6	decreased CD4-positive, alpha-beta T cell number	J:174536
	decreased CD8-positive, alpha-beta T cell number	J:174536
	decreased DN4 thymocyte number	J:174536
	decreased double-negative T cell number	J:174536
	decreased double-positive T cell number	J:174536
	decreased gamma-delta T cell number	J:174536
	decreased T cell proliferation	J:174536
	decreased thymocyte number	J:174536
Sos1tm1.2Rak/Sos1+ involves: 129S/Sv * C57BL/6 * FVB/N * SJL	abnormal cardiovascular system physiology	J:171873
	abnormal common myeloid progenitor cell morphology	J:171873
	abnormal craniofacial morphology	J:171873
	abnormal erythropoiesis	J:171873
	abnormal fetal cardiomyocyte proliferation	J:171873
	abnormal frontal bone morphology	J:171873
	abnormal heart left ventricle morphology	J:171873
	abnormal heart morphology	J:171873
	abnormal myocardial fiber morphology	J:171873
	aortic valve stenosis	J:171873
	cardiac fibrosis	J:171873
	cardiac interstitial fibrosis	J:171873
	normal cardiovascular system phenotype	J:171873
	decreased body length	J:171873
	decreased body size	J:171873
	decreased body weight	J:171873
	decreased cranium height	J:171873
	enlarged spleen	J:171873
	extramedullary hematopoiesis	J:171873
	heart left ventricle hypertrophy	J:171873
	hemorrhage	J:171873
	increased cardiomyocyte apoptosis	J:171873
	increased leukocyte cell number	J:171873
	increased megakaryocyte cell number	J:171873
	increased myocardial fiber size	J:171873
	increased neutrophil cell number	J:171873
	increased spleen red pulp amount	J:171873
	ocular hypertelorism	J:171873
	pericardial effusion	J:171873
	skin edema	J:171873
	thick aortic valve cusps	J:171873
	thick interventricular septum	J:171873
Sos1tm1.2Rak/Sos1tm1.2Rak involves: 129S/Sv * C57BL/6 * FVB/N * SJL	abnormal cardiovascular system physiology	J:171873
	abnormal craniofacial morphology	J:171873
	abnormal fetal cardiomyocyte proliferation	J:171873
	abnormal frontal bone morphology	J:171873
	abnormal heart morphology	J:171873
	aortic valve stenosis	J:171873
	cardiac fibrosis	J:171873
	decreased body length	J:171873
	decreased body size	J:171873
	decreased body weight	J:171873
	decreased cranium height	J:171873
	embryonic lethality during organogenesis, incomplete penetrance	J:171873
	heart right ventricle hypertrophy	J:171873
	hemorrhage	J:171873
	lethality throughout fetal growth and development, incomplete penetrance	J:171873
	myocardial fiber degeneration	J:171873
	ocular hypertelorism	J:171873
	ostium secundum atrial septal defect	J:171873
	pericardial effusion	J:171873
	premature death	J:171873
	skin edema	J:171873
	thick aortic valve cusps	J:171873
	thick interventricular septum	J:171873
	ventricular septal defect	J:171873
Sos1tm1Dlb/Sos1tm1Dlb involves: 129S1/Sv * 129X1/SvJ	abnormal blood vessel morphology	J:38321
	abnormal cardiovascular system morphology	J:38321
	abnormal heart atrium morphology	J:38321
	abnormal heart position or orientation	J:38321
	abnormal heart ventricle morphology	J:38321
	abnormal midbrain morphology	J:38321
	abnormal myocardial trabeculae morphology	J:38321
	blood vessel congestion	J:38321
	cleft palate	J:38321
	decreased embryo size	J:38321
	distended pericardium	J:38321
	enlarged heart	J:38321
	hemorrhage	J:38321
	pale yolk sac	J:38321
	prenatal lethality, complete penetrance	J:38321
Sos1tm1Dlb/Sos1tm1Dlb involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal blood vessel morphology	J:38321
	abnormal heart atrium morphology	J:38321
	abnormal heart position or orientation	J:38321
	abnormal heart ventricle morphology	J:38321
	abnormal midbrain morphology	J:38321
	abnormal myocardial trabeculae morphology	J:38321
	blood vessel congestion	J:38321
	cleft palate	J:38321
	decreased embryo size	J:38321
	enlarged heart	J:38321
	enlarged pericardium	J:38321
	hemorrhage	J:38321
	pale yolk sac	J:38321
	prenatal lethality, complete penetrance	J:38321
Sos1tm1Lowy/Sos1tm1Lowy involves: 129S4/SvJae * C57BL/6N	abnormal extraembryonic tissue morphology	J:60649
	embryonic lethality during organogenesis, complete penetrance	J:60649