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Snap25 Gene Detail
Summary
  • Symbol
    Snap25
  • Name
    synaptosomal-associated protein 25
  • Synonyms
    Bdr, GENA 70, SNAP-25, sp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98331
    NCBI Gene: 20614
  • Gene Overview
    MyGene.info: SNAP25
Location & Maps
more
  • Sequence Map
    Chr2:136713453-136782428 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68976 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 67.56 cM
  • Mapping Data
    18 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    SNAP25, synaptosome associated protein 25
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNAP25, synaptosome associated protein 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA416N4.2, CMS18, dJ1068F16.2, RIC4, RIC-4, SEC9, SNAP, SNAP-25, SUP
  • Links
    NCBI Gene ID: 6616
    neXtProt AC: NX_P60880

  • Chr Location
    20p12-p11.2; chr20:10218829-10307420 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Snap25 mouse models; 1 with human SNAP25 associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Obesity   OMIM: 601665 View 1 model
Schizophrenia; SCZD   OMIM: 181500 View 1 model
       Myasthenic Syndrome, Congenital, 18; CMS18   OMIM: 616330
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 8 alleles in 11 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    9
  • Transgenic
    1
  • Genomic Mutations
    3 involving Snap25
  • Incidental Mutations
Homozygotes for a targeted null mutation are small size, blotchy in appearance, have dilated vascular channels, and brain defects, lack spontaneous or reflexive movement and evoked neurotransmitter release at E18.5, and die at birth. An ENU-induced mutant displays neurological abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015556 VEGA Gene Model | MGI Sequence Detail 68976 C57BL/6J ±  kb
transcript OTTMUST00000036955 VEGA | MGI Sequence Detail 2116 Not Applicable  
polypeptide OTTMUSP00000016582 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    475 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015312 synaptosomal-associated protein 25
  • PDB
  • InterPro Domains
    IPR000928 SNAP-25
    IPR000727 Target SNARE coiled-coil homology domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14461, MGI:1861990
References
more
  • Summaries
    All 149
    Developmental Gene Expression 43
    Diseases 5
    Gene Ontology 26
    Phenotypes 62
  • Earliest
    J:27204 Oyler GA, et al., The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol. 1989 Dec;109(6 Pt 1):3039-52
  • Latest
    J:230661 Gabanyi I, et al., Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell. 2016 Jan 28;164(3):378-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory