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Snap25
Gene Detail
 Symbol
Name
ID
Snap25
synaptosomal-associated protein 25
MGI:98331
STS D2Mit28, D2Nds33
Synonyms Bdr, GENA 70, SNAP-25, sp
Feature Type protein coding gene
Genetic Map
Chromosome 2
67.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr2:136713453-136782428 bp, + strand
From VEGA annotation of GRCm38

  68976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13311  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: synaptosomal-associated protein 25
Gene Tree: Snap25

Human
homologs
Human Homolog SNAP25, synaptosomal-associated protein, 25kDa
NCBI Gene ID 6616
neXtProt AC  NX_P60880
Human Synonyms  bA416N4.2, dJ1068F16.2, RIC4, RIC-4, SEC9, SNAP, SNAP-25
Human Chr (Location)  20p12-p11.2; chr20:10218694-10307418 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Targeted(8) Chemically induced(1)
 
Homozygotes for a targeted null mutation are small size, blotchy in appearance, have dilated vascular channels, and brain defects, lack spontaneous or reflexive movement and evoked neurotransmitter release at E18.5, and die at birth. An Enu-induced mutant displays neurological abnormalities.
 
Human Diseases Modeled Using Mouse Snap25 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, endosomal transport, ...
Component actin cytoskeleton, axon, ...
Function myosin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (269)    Tissues (75)    Images (39)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 212
Western blot 53
RT-PCR 2
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015556 (Evidence)
Ensembl Gene ModelENSMUSG00000027273 (Evidence)
Entrez Gene20614 (Evidence)
DFCITC1572181, TC1596567, TC1603564
DoTSDT.101387014, DT.101387015, DT.50316598, DT.91347384, DT.94356649
NIA Mouse Gene IndexU002531
PDB2BU0
Consensus CDS ProjectCCDS16793.1
International Mouse Knockout Project StatusSnap25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015556 VEGA Gene Model | MGI Sequence Detail 68976 C57BL/6J ±  kb
transcript OTTMUST00000036955 VEGA | MGI Sequence Detail 2116 Not Applicable 
polypeptide OTTMUSP00000016582 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(1)
Polymorphisms RFLP(5) : SNPs within 2kb(475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000928 SNAP-25
InterPro IPR000727 Target SNARE coiled-coil domain
Protein Ontology PR:000015312 synaptosomal-associated protein 25
References (Earliest) J:27204 Oyler GA, et al., The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol. 1989 Dec;109(6 Pt 1):3039-52
(Latest) J:197846 Jurado S, et al., LTP requires a unique postsynaptic SNARE fusion machinery. Neuron. 2013 Feb 6;77(3):542-58
All references(128)
Other
accession IDs
MGD-MRK-14461, MGI:1861990

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory